Obasanjo-Bello was elected to the Senate on 28 April 2007 on a People's Democratic Party platform; her Action Congress opponent Remilekun Bakare challenged this outcome, but the Ogun State Election Petition Tribunal upheld her victory. She was the Chairman of the Senate's Health Committee, and a member of the Security & Intelligence, Land Transport, Science & Technology, Education, National Planning, and Inter-Parliamentary Committees. She lost her seat during the National Assembly Elections on 9 April 2011.
Assassination attempt
In April 2003 on the day of the general elections her car was shot at on Ifo Road in Ogun State. She was not in the car but 3 adults and 2 children in the car died. The perpetuators were never caught.
SCANDALS
Recently,a letter sent by Iyabo Obasanjo to her father in 2013 resurfaced after a statement sent by her father to the present president of Nigeria and she blamed it on the supporters of the present administration. She also said the present administration should heed her fathers advice and not run for Election.
EFCC investigation
In April 2008, Obasanjo-Bello came under investigation by Nigeria's Economic and Financial Crimes Commission due to the investigations involving the Former Minister for Health and her minister for Health, Prof. Adenike Grange, for embezzlement of public funds. The Ministry at the end of the financial year did not return all unspent funds to the government coffers. The amount was 300 million Naira, which was allegedly distributed among the Minister, her minister of state and top civil servants on the Senate and House Health Committee she chairs. The Minister and her deputy were forced to resign after returning their share of the money; they were later arrested and posted bail. Iyabo Obasanjo-Bello refused to return her portion of this money, 10 million naira. She claimed that the nine members of her committee "lobbied" for funds from the ministry they oversaw. She maintained this money was spent on a conference on capacity building some members of the health committee attended in Ghana. She has so far refused to appear before the EFCC. Although summoned, along with the minister and other civil servants, she refused to appear in court. A week later a high drama ensued when officials of the EFCC tried to arrest her at her home in the Maitama district of Abuja city, after several simultaneous stake outs by law enforcement officials that had her jumping over her fence to evade arrest by Nigerian law enforcement officers. In 2009 the case was thrown out of the High Court in Abuja as having no merit. Obasanjo-Bello described the allegation as "blackmail", and said she was being targeted because she was the daughter of the former president.
Academic career
She worked in Clinical Research in the US before returning to Nigeria in 2003. she was a Fellow and for 2013 a Senior Fellow at Harvard's Advanced Leadership Initiative. Her noted works include: