Sprenger was admitted as a novice in the Dominican house of Rheinfelden in 1452 and became a zealous reformer. He founded an association of the Confraternity of the Holy Rosary in Strasbourg in 1474.
In 1481 he was appointed as an Inquisitor for the Provinces of Mainz, Trier and Cologne, a post that demanded constant traveling through an extensive district.
Associated authorship of ''Malleus Maleficarum''
Sprenger was named along with Heinrich Kramer in the 1484 papal bullSummis desiderantes of Pope Innocent VIII and reprinted in the infamous Malleus Maleficarum. All editions after 1519 named Sprenger as Heinrich Kramer's co-author. It has been claimed that Sprenger cannot be linked to any witch trial, that his personal relationship to Kramer was acrimonious, and that Sprenger used his powerful position whenever he could to make Kramer's life and work as difficult as possible. Some scholars now believe that he became associated with the Malleus Maleficarum largely as a result of Kramer's wish to lend his book as much official authority as possible.
In a 1631 work most concerned with innocence, and opposed to the Malleus Maleficarum, Friedrich Spee attributes authorship of the notorious book to "Jacob Sprenger and Heinrich Kramer." Though Spee was Jesuit and his work was written more than a century after Malleus Maleficarum, both Spee and Sprenger were professors of theology in Cologne and both travelled extensively in many of the same areas. Some of Spee's fellow professors in Cologne were appalled by Spee's book and thought it should be listed on the papal Index of Forbidden Books. This would suggest that, whether or not Sprenger initially endorsed or opposed the work of Heinrich Kramer, the book carrying Sprenger's name did eventually find a degree of influence among the Catholic theologians in Cologne.
The Harvard President and PuritanIncrease Mather cited "Sprenger" as a reference to the Malleus Maleficarum in an influential witch-phobic work published in 1684, as well as another work published in 1692, the same year as the Salem Witch Trials: "Witches have often desired that they might stand or fall by this trial by hot iron, and sometimes come off well."