Janet Thornton
Dame Janet Maureen Thornton, is a senior scientist at the European Bioinformatics Institute, part of the European Molecular Biology Laboratory. She is one of the world's leading researchers in structural bioinformatics, using computational methods to understand protein structure and function. She was formerly director of the EBI from October 2001 to June 2015, and played a key role in ELIXIR.Education
After graduating in physics from the University of Nottingham, Thornton completed a master's degree in biophysics at King's College London, and a PhD in Biophysics at the National Institute for Medical Research, Mill Hill, London in 1973.Career and research
After her PhD, Thornton worked in molecular biophysics with David Chilton Phillips at the University of Oxford. In 1978, she returned to the National Institute for Medical Research, and following that took up to a Fellowship at Birkbeck College, part of the University of London. In 1990 she was appointed Professor and Director of the Biomolecular Structure and Modeling Unit in the Department of Biochemistry and Molecular Biology at University College London and later also was appointed to the Bernal Chair in the Crystallography Department at Birkbeck College.
Thornton was Director of the European Bioinformatics Institute from 2001 to 2015, on the Wellcome Trust Genome Campus at Hinxton near Cambridge.
She was an organiser of the Intelligent Systems for Molecular Biology and European Conference on Computational Biology joint Conference in Glasgow in 2004.
Thornton's work is highly interdisciplinary, interfacing with structural biology, bioinformatics, biological chemistry and chemoinformatics, amongst others. She was an early pioneer in structure validation for protein crystallography, developing the widely used ProCheck software. Together with Christine Orengo, she introduced the CATH classification of protein structure. Her group developed a robust enzyme classification, comparison and annotation tool – the EC-BLAST which calculates similarity between enzymes based on chemical reactions by capturing the bond change, reaction centre or structural similarity between them.
From 2008 to 2012, she co-ordinated the four-year preparatory phase of the European life sciences data infrastructure ELIXIR. As of 2013 she remains on the ELIXIR board as one of EMBL's scientific delegates. Her research has been funded by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, and the European Union.Thornton has supervised several PhD and postdoctoral researchers including Sarah Teichmann and David Tudor Jones.Awards and honours
Thornton was elected Fellow of the Royal Society in 1999. She became a member of the European Molecular Biology Organisation in 2000, a foreign associate of the US National Academy of Sciences in 2003, and a Fellow of the Academy of Medical Sciences in 2014. Thornton is a Fellow of Churchill College, Cambridge. She was elected a Fellow of the Royal Society of Chemistry in 2017. Thornton's nomination for the Royal Society reads
Her citation on election to the Academy of Medical Sciences reads:
Thornton was appointed Commander of the Order of the British Empire in 2000 and Dame Commander of the Order of the British Empire in the 2012 Birthday Honours for services to bioinformatics. The Times named Thornton number 86 of their "Eureka 100" British scientists in 2010.
