Piccola served as a member of the Pennsylvania House of Representatives for the 104th district from 1977 to 1995. He served as a member of the Pennsylvania State Senate for the 15th district from 1995 to 2012. He was made Majority Caucus Administrator of the State Senate in 1999. In 2001, he was elected Senate Majority Whip. He was considered a "eader of the impatient hard right wing of the Pennsylvania Republican Senate." In 2002, the political website PoliticsPA named him to the list of "Smartest Legislators," saying that he was known for being "rticulate and quick on his feet." In a 2002 PoliticsPA feature story designating politicians with yearbook superlatives, he was named the "Most Likely to Succeed." In 2005, Piccola announced that he would run for Governor, seeking the Republican nomination against incumbent DemocraticGovernor Ed Rendell. Piccola dropped out of the race for governor in early 2006, after it became clear that former professional football playerLynn Swann had earned the support of most of the Pennsylvania Republican Party. Following the 2006 elections, Piccola gave up his position as Senate Whip, and instead made a bid to become president pro tempore of the State Senate, after the sitting president pro tempore, Bob Jubelirer, lost the Republican Primary in his home district. State Senate Republicans ultimately chose Senator Joe Scarnati for the president pro tempore position instead of Piccola. Piccola was replaced as Republican Whip by Jane Orie. Piccola considered running for a spot on the State Supreme Court in 2007 but withdrew after he was unable to secure support for the state committee endorsement. In 2009, the Pennsylvania Report noted that Piccola had been "left for dead" after the 2006 leadership election, but was able to return to a leadership role as Chairman of the SenateEducation Committee. In 2012, he received a public reprimand from the Disciplinary Board of the State Supreme Court due to his conduct as a private attorney. He was reprimanded for violations to the code of conduct for lawyers by representing a Utah-based "heir-hunting" firm while also representing three clients involved in estate settlements. The public reprimand was the result of an agreement that allowed Piccola to keep his lawyer license and the dismissal of more serious charges of fraud, dishonesty and champery. Piccola did not seek re-election in 2012, and was succeeded by Democrat Rob Teplitz.