Syme was born in Pico Rivera, California, where she lived for the first eighteen years of her life. Shortly after moving to Los Angeles, she landed a job working for director David Lynch. Syme had a few minor film roles including a part in Lynch's Lost Highway. She later joined the staff of a music label. She was also a personal assistant to Dave Navarro of Jane's Addiction and, later, the Red Hot Chili Peppers. On December 24, 1999, she gave birth eight months into her pregnancy to Ava Archer Syme-Reeves, her child with actor Keanu Reeves. The child was stillborn. The strain put on their relationship by their grief resulted in their breakup several weeks later.
Death
On April 1, 2001, Syme attended a party at musician Marilyn Manson's home. After being driven home by another party guest shortly before dawn, she left her home, reportedly to return to the party. On the morning ofApril 2, Syme drove her 1999 Jeep Grand Cherokee into a row of parked cars on Cahuenga Boulevard in Los Angeles. She was partially ejected from the vehicle and died instantly. Syme was 28 years old. Syme is buried next to her daughter in Westwood Village Memorial Park Cemetery in Los Angeles. An investigation into the collision concluded that Syme was not wearing a seatbelt and was inebriated at the time. Reports also stated that police found two rolled up dollar bills that contained a white, powdery substance and two bottles of prescription drugs, a muscle relaxant and an anticonvulsant. Syme's mother told police her daughter was seeking treatment for back pain and depression just a few days prior to her death.
Aftermath
In tribute to Syme's memory, David Lynch dedicated the 2001 filmMulholland Drive to her. In April 2002, Syme's mother, Maria St. John, sued Marilyn Manson for wrongful death for giving Syme "various quantities of an illegal controlled substance" and for "instructing to operate a motor vehicle in her incapacitated condition". Shortly after the lawsuit was filed, Manson issued a statement denying responsibility for Syme's death, stating that the lawsuit was "completely without merit".