On May 15, 2007, Litsch made his Major League debut with the Blue Jays, filling in for the injured Roy Halladay. Over 8 innings, Litsch allowed only 4 hits, with 2 walks and 1 run while recording 21 of his 26 outs via groundouts. Litsch became the first Blue Jays pitcher to win his debut since Gustavo Chacín beat the New York Yankees on September 20, 2004. As a result of his performance, Litsch made three more starts with the Jays. He was demoted back to Double-A after posting a 0–3 record with a 19.62 ERA in those three starts. After an injury to A. J. Burnett, the Blue Jays recalled Litsch and he started against Boston on July 15, 2007. He yielded one run on 9 hits over 6 innings with 2 strikeouts and 1 walk, defeating Josh Beckett and the Boston Red Sox 2–1. He came home to Tampa Bay on July 31, going 6 innings, giving up 7 hits while walking 1 and striking out 2, with no earned runs. Litsch finished his first year in the majors 7–9 with a 3.89 ERA and 50 K/36 BB over 20 starts.
2008–2010
On May 24, 2008, the same day that Litsch pitched his first complete game and shutout, he also surpassed Jimmy Key's former franchise record by pitching 38 consecutive innings without walking a batter. In 2008, he threw cutters 43.4% of the time, the highest rate in the majors. Litsch would finish the 2008 season with a record of 13–9, a 3.58 ERA, and 99 strikeouts. On April 14, 2009, he was sent to the 15-day DL because of a right forearm strain. On June 9, it was announced that Litsch would undergo season-ending Tommy John surgery. He made his first major league start since surgery on June 13, 2010 against the Colorado Rockies. Litsch struggled against the Rockies in his return from injury. He lasted only 2 innings and allowed 7 runs on 9 hits. He regained his previous form in his next start against the San Francisco Giants on June 19 by going seven solid innings, allowing three hits in a 3-0 win.
2011–retirement
Litsch was named the number 5 starter for the 2011 season. He made his 2011 debut on April 6 against the Oakland Athletics, getting the win and giving up 6 hits and 3 earned runs while striking out 7. He finished off the season with a 4.44 ERA and a 6-3 win-loss record over 75 innings pitched. Litsch suffered a setback with his injured right shoulder early in 2012 training camp, and was shut down because of inflammation. He visited surgeon Dr. James Andrews for a full diagnosis that confirmed the inflammation and didn't find any structural damage. Litsch received a platelet-rich plasmas injection to help with the healing process. The injection caused an unexpected serious infection, and Litsch was not allowed to throw for six weeks after undergoing emergency surgery. The infection sidelined him for the entire 2012 season. On October 10, 2012, the Blue Jays announced that Litsch was coming off the 60-day disabled list, but had chosen free agency over an assignment to their Triple-A affiliate Buffalo Bisons. In December 2012, it was reported that Litsch was awaiting bone-graft and cartilage replacement surgery from a donor cadaver, and his career was in serious jeopardy. The surgery was performed on January 17, 2013, and Litsch was reported to be hopeful to pitch winter ball in late 2013. On August 21, 2014, Litsch announced his retirement. He threw out the ceremonial first pitch of the Blue Jays-Rays game on September 2, 2014.
Coaching
After retiring, Litsch coached middle and high school players at a Major League Baseball development center in China. In January 2016, he announced that he would be the pitching coach for the Philippines national baseball team in their February World Baseball Classic qualifier. On March 1, 2016, the Bridgeport Bluefish hired Litsch to be their pitching coach for the 2016 season.
Pitch repertoire
Litsch's main pitch was his four-seam fastball, and could throw a two-seam fastball with considerable movement. He often used a cutter and a curveball, and struggled with command of his changeup.
