Jim Cuthbert Smith


Sir James Cuthbert Smith is Director of Science at the Wellcome Trust and Senior Group Leader at the Francis Crick Institute.

Education

Smith was educated at Latymer Upper School and graduated from the University of Cambridge with a Bachelor of Arts degree in Natural Sciences in 1976. He was awarded a PhD in 1979 by University College London for research supervised by Lewis Wolpert at Middlesex Hospital Medical School.

Career and research

Smith completed postdoctoral research appointments at Harvard Medical School from 1979 to 1981 and the Imperial Cancer Research Fund from 1981 to 1984. In 1984 he joined the staff of the National Institute for Medical Research, becoming head of the Division of Developmental Biology in 1991 and head of the Genes and Cellular Control Group in 1996. He moved to become director of the Gurdon Institute in 2001, returning to NIMR in 2009 to become its director. In 2014 he became Deputy CEO of the Medical Research Council. When NIMR joined the CRUK London Research Institute as part of the Francis Crick Institute he became Director of Research at the Crick. He took up his present roles in December 2016.
Smith's research has focused on how cells of the very early vertebrate embryo form the specialised tissues of muscle, skin, blood and bone. His discovery of a mesoderm-inducing factor secreted by a cell line and establishing its identity as activin transformed the study of induction in the early embryo. He also showed that activin specifies different cell types at different thresholds and that characteristic genes like Brachyury are turned on at specific concentrations. In other work he shed light on the molecular basis of gastrulation, and especially the role of non-canonical Wnt signalling. His earlier work demonstrated threshold responses in chick limb development and also showed that the mitogenic response to growth factors can be active when attached to the extracellular matrix.

Awards and honours

Smith was elected a Fellow of the Royal Society in 1993 and of the Academy of Medical Sciences in 1998. He was awarded the Feldberg Foundation award in 2000, the William Bate Hardy Prize in 2001 and the Waddington Medal by the British Society for Developmental Biology in 2013. In 2014 he was named by the London Evening Standard as one of the 1000 most influential Londoners, in the 'Innovators' section. He was also awarded the EMBO Gold Medal in 1993.
Smith was knighted in the 2017 New Year Honours for services to medical research and science education.

Personal life

Smith married Fiona Watt in 1979 and has three children.