Johannes Kornhuber


Johannes Kornhuber is a German psychiatrist and psychotherapist.

Life

Kornhuber worked in the Department of Psychiatry at the University of Würzburg, Germany, as Postdoctoral Fellow, Resident and Supervising Physician. In 1996 he obtained an appointment to a full professorship in the Department of Psychiatry at the University of Göttingen, Germany, where he was Chairman of the Gerontopsychiatric Section. Since 2000, Kornhuber has been a full professor and chairman in the Department of Psychiatry at the University of Erlangen-Nuremberg, Germany.

Work

His research interests include the pathophysiology of Alzheimer’s disease, the early diagnosis and treatment of dementia syndromes, the pathophysiology of alcohol addiction and the pathophysiology of major depressive disorder. He has authored or co-authored more than 400 Journal articles. Kornhuber described novel molecular mechanisms of approved psychotropic drugs, namely that memantine, amantadine, budipine and orphenadrine act as low-affinity NMDA-receptor antagonists. The data obtained with memantine formed an important basis for its worldwide approval as an antidementive drug. Kornhuber developed the pharmacokinetic hypothesis explaining the delayed therapeutic effects of antidepressant drugs. Furthermore, he found that antidepressant drugs like amitriptyline and fluoxetine mediate their effects on neurogenesis and behavior by lowering ceramide abundance in the brain. Among his coauthors has been Peter Riederer.

Honors