Altschuler grew up in a Jewish family in Carbondale, Illinois. He then moved with his family to Cary, North Carolina, later attended the University of North Carolina at Chapel Hill, and co-created the first student-produced comedy show on UNC Student Television. He began his career as a writer for the humour magazine National Lampoon, together with Dave Krinsky, whom he met and began collaborating creatively with while at UNC-Chapel Hill, which became a collaboration that continued in the years to come. After selling their screenplays to Warner Brothers, Universal and Studio Canal Plus, they moved to Hollywood and began working as assistant producers for the HBO seriesThe High Life. In 1997, Altschuler and Krinsky became writers on 20th Century Fox’s King of the Hill. They worked there for 13 years and ran the show for the final seven seasons. In 2008, they formed Ternion Productions, a film and television production company with Mike Judge. In 2009, Altschuler, Judge, and Krinsky co-created the show The Goode Family. In 2011, they executive produced and wrote several episodes of MTV’s return of Beavis and Butt-head. Altschuler and Krinsky also co-wrote various features, including Role Models, Blades of Glory and Extract. He also produced the Napoleonic War comedy The Adventures of Brigadier Gerard from his script based on the short stories of Sir Arthur Conan Doyle. In 2013, Altschuler, Judge, and Krinsky co-created the HBO series Silicon Valley. In addition, they are working on an animated Woody Woodpecker feature. They are also writing and producing Brigadier Gerard, a feature with Steve Carell attached to play Brigadier Gerard and Ricky Gervais attached to play Napoleon. In 2015, Altschuler, Krinsky and Jeff Stilson co-created the sitcom series Lopez, starring George Lopez. TV Land gave a 12-episode straight-to-series order in August 2015. The series premiered on March 30, 2016. On June 3, 2016, TV Land renewed Lopez for a second season. Altschuler has received several Emmy nominations and has won an Environmental Media Award, and also a SXSW Film Award, which was shared along with Krinsky and Carson D. Mell for their writing work for Silicon Valley.