Brett was born near Reigate on 8 December 1831, the son of an army vet. His sister Rosa Brett was also an artist and during 1850 and 1851 they shared a studio. In 1851 he began lessons in art with James Duffield Harding, a landscape painter. He also studied with Richard Redgrave. In 1853 he entered the Royal Academy schools, but was more interested in the ideas of John Ruskin and William Holman Hunt, whom he met through his friend the poet Coventry Patmore. Inspired by Hunt's ideal of scientific landscape painting, Brett visited Switzerland, where he worked on topographical landscapes and came under the further influence of John William Inchbold. In 1858 Brett exhibited The Stonebreaker, the painting that made his reputation. This depicted a youth smashing stones to create a road-surface, sitting in a brightly lit and brilliantly detailed landscape. The precision of the geological and botanical detail in Brett's version greatly impressed Ruskin, who praised the painting highly, predicting that Brett would be able to paint a masterpiece if he were to visit the Val d'Aosta in Italy. Partly funded by Ruskin, Brett made the trip to paint the location, exhibiting it in 1859, again to high praise from Ruskin, who bought the painting. Other critics were less effusive, one describing it as a "gravestone for post-Ruskinism". Brett continued to paint carefully detailed landscape views, staying in Italy on many occasions in the 1860s. He was always keen to stress the scientific precision of his rendering of nature, but often infused it with moral and religious significance, as recommended by Ruskin. In his later years he painted more coastal subjects and seascapes, subjects he came to know well due to his ownership of a 210-ton schooner, Viking, on which he travelled the Mediterranean. During summers in the 1880s Brett rented the castle at Newport, Pembrokeshire to use as a base for his large family while he painted, sketched and photographed the south and west coasts of Wales. An exhibition in 2001 at the National Museum of Wales, Cardiff, entitled John Brett - a Pre-Raphaelite on the Shores of Wales brought together many of the major works from this period of his career. Brett was also a keen astronomer, having studied the subject from childhood. He was elected a Fellow of the Royal Astronomical Society in 1871. Brett was a founder member of the Art Workers' Guild and Master in 1890.