John L. LeFlore was born and raised in Mobile, attending local black segregated schools. As an adult he started working for the US Postal Service, which was considered a good position. In 1925 he founded the local chapter of the National Association for the Advancement of Colored People, leading it for decades and working to improve civil rights for the black community. In 1956 the state attorney general and state courts forced the NAACP to stop operating in the state. LeFlore and others founded the Non-Partisan Voting League that year in Mobile to carry on the civil rights struggle. Among its activities was to promote election of better candidates in elections. In 1957 LeFlore introduced what were known as "pink sheets," which gave information and endorsement of candidates in city elections. The NPVL recommended election of Joseph N. Langan as a commissioner, who had already formed an alliance with LeFlore to promote civil rights in the city. He served four terms as city commissioner, continuing to work with LeFlore on voting rights, hiring of blacks as municipal employees, and integration of public facilities. From 1959 until his death, LeFlore was director of casework for the NPVL. He conducted investigations of social issues, initiated court proceedings, and acted as spokesman of the organization. During this period, the NPVL worked to increase hiring of black employees in city government, sued for desegregation of the Mobile public school system after the US Supreme Court ruling in Brown v. Board of Education, "filed complaints with the U.S. Department of Justice to open public accommodations to all, launched massive voter registration drive campaigns to bring large numbers of African Americans into the political process..." In 1974, nearly a decade after passage of the Voting Rights Act of 1965 expanded participation by African Americans in politics in the South, Langan was elected to the Alabama House of Representatives as a Democrat. He served in that position until his death in 1976. In 1975 the NPVL initiated a legal challenge to Mobile's city commissionform of government, saying that the at-large voting for three commissioners prevented the African-American minority from electing representatives of their choice. After a long court battle, in 1985 voters approved a mayor-city council form of government in a referendum. That year elections were held for seven city council seats from single-member districts, and three African Americans were elected to office for the first time in the city government. The position of mayor was elected at-large, also for a four-year term.
A statue of him and Joseph Langan was dedicated in August 2009 by city officials at Unity Point Park in Mobile to commemorate their work together to advance civil rights in the city.