Neale was born in London on 24 January 1818, his parents being the clergyman Cornelius Neale and Susanna Neale, daughter of John Mason Good. A younger sister Elizabeth Neale founded the Community of the Holy Cross. He was educated at Sherborne School, Dorset, and Trinity College, Cambridge, where his lack of ability in mathematics prevented him taking an honours degree. Neale was named after the Puritan cleric and hymn writer John Mason, of whom his mother Susanna was a descendant. At the age of 22 Neale was the chaplain of Downing College, Cambridge. At Cambridge he was affected by the Oxford Movement and, particularly interested in church architecture, helped to found the Cambridge Camden Society. The society advocated for more ritual and religious decoration in churches, and was closely associated with the Gothic Revival. Neale was ordained in 1842. He was briefly incumbent of Crawley in Sussex, but was forced to resign due to a chronic lung disease. The following winter he lived in the Madeira Islands, where he was able to do research for his History of the Eastern Church. In 1846 he became warden of Sackville College, an almshouse at East Grinstead, an appointment which he held until his death. In 1854 Neale co-founded the Society of Saint Margaret, an order of women in the Church of England dedicated to nursing the sick. Many Protestants of the time were suspicious of the restoration of Anglican religious orders. In 1857, Neale was attacked and mauled at a funeral of one of the Sisters. Crowds threatened to stone him or to burn his house. He received no honour or preferment in England, and his doctorate was bestowed by Trinity College. He was also the principal founder of the Anglican and Eastern Churches Association, a religious organization founded as the Anglican and Eastern Orthodox Churches Union in 1864. A result of this organisation was the Hymns of the Eastern Church, edited by John Mason Neale and published in 1865. Neale was strongly high church in his sympathies, and had to endure a good deal of opposition, including a fourteen years' inhibition by his bishop. Neale translated the Eastern liturgies into English, and wrote a mystical and devotional commentary on the Psalms. However, he is best known as a hymnwriter and, especially, translator, having enriched English hymnody with many ancient and mediaeval hymns translated from Latin and Greek. For example, the melody of Good King Wenceslas originates from a medieval Latin springtime poem, Tempus adest floridum. More than anyone else, he made English-speaking congregations aware of the centuries-old tradition of Latin, Greek, Russian, and Syrian hymns. The 1875 edition of the Hymns Ancient and Modern contains 58 of his translated hymns; The English Hymnal contains 63 of his translated hymns and six original hymns by Neale. His translations include:
