While his father ran the fledgling Times newspaper, the younger Bryan graduated in 1893 from the University of Virginia in Charlottesville and obtained a law degree from Harvard University in 1897. After a brief stint as a lawyer in New York, he returned to Richmond in 1898 to form a joint practice with Murray Mason McGuire. He then quit law to work for his father's newspaper company in 1900.
In 1926 Bryan became a member of the board of visitors of the College of William and Mary in Williamsburg. Early in the 1930s, as vice rector, he served under the erratic leadership of President Julian Alvin Carroll Chandler. Following Chandler's death, the board named Bryan president of the college on June 30, 1934. Bryan became the nineteenth president of the College of William and Mary, serving until 1942. He also served as the fourth American chancellor of the college from 1942 to 1944. In addition to the financial struggles of the Great Depression, Bryan's tenure was also marked by the recent establishment and beginnings of Colonial Williamsburg. Largely thanks to the vision of a William and Mary instructor, Reverend Dr. W. A. R. Goodwin and the substantial financial support from John D. Rockefeller Jr. and his wife, Abby Aldrich Rockefeller, the William and Mary Campus had seen substantial construction on campus from 1928 to 1932, as historic buildings were restored to their 18th-century appearance. Significant campus construction continued under Bryan, including the 1935, Sunken Garden designed by Charles M. Robinson. His papers from his service as president and chancellor of the College of William and Mary are held by the Special Collections Research Center at the College of William and Mary.
Later career
In 1940, towards the end of Bryan's tenure as president of William and Mary, Richmond, Virginia's two newspapers, the Times-Dispatch and News Leader, merged to form Richmond Newspapers a majority of which was owned by the Bryan family. This conglomerate would later be known as Media General.
Death and legacy
Bryan died in October 16, 1944 leaving the newspapers to his son D. Tennant Bryan. Other life contributions included:
sat on the board of visitors of the University of Virginia from 1918 to 1920—was rector from 1920 until 1922
In 1922 and 1923 John Stewart Bryan became president of the Richmond Public Library Association and then the chairman of the Richmond Public Library Board. He led the fundraising to build the first Richmond Public Library, which opened in 1924.