Born in Lisbon, Andrade made his professional debuts with hometown club C.F. Estrela da Amadora in 1997, helping it to two consecutive eighth Primeira Liga places. He immediately caught the eye, and after that was on the move north to FC Porto, being the team's most used player in the 2001–02 UEFA Champions League by playing 12 times as they reached the second group phase in the competition.
Deportivo
After Portugal's unsuccessful 2002 World Cup campaign, Andrade was acquired by Spain's Deportivo de La Coruña in a move that cost the Galician side €12 million with the possibility of being increased to €13M. He appeared in only 11 La Liga games in his debut season, barred by César Martín and Noureddine Naybet, but was an undisputed first-choice when healthy in the following years. On 21 April 2004, during a Champions League semi-finals match against former team Porto, Andrade was sent off by Markus Merk for a kick on Deco. The gesture was of a friendly nature, but the referee was eluded by it, and immediately gave the defender his marching orders. He was forced to serve a one-match ban.
Juventus
Andrade signed for Juventus F.C. in summer 2007, for approximately €10 million. In a Serie A match against A.S. Roma on 23 September, he badly broke his left kneecap and missed the rest of the 2007–08 season. In the team's 2008 pre-season, Andrade suffered the same injury and missed the entire 2008–09. In a press release dated 7 August, Juventus stated:
"On 9 July 2008, during a training session at Pinzolo, the player Jorge Manuel Almeida Gomes de Andrade was the victim of another serious injury to his left knee operated twice in the past season. A new osteosynthesis operation was thus needed, with the post-surgery prognosis being a number of months. Given the impossibility for the player to recover to play professionally, the company has proceeded to fully write down the residual book value of the player's registration rights with a negative effect on the 2007–08 financial year for €6.8 million."
That was the third in a year and the fourth left knee surgery Andrade had in his career. The Turin-based club wrote off his salary as well as part of the transfer fee for the fiscal year, though he stated he hoped to return playing at the highest level. On 8 April 2009, Juventus and Andrade reached an agreement and the player's remaining contract was cancelled, leaving him free to find another team. After being released he went on trial with Málaga CF, but was not offered a deal eventually; in early February 2010, he was scheduled to undergo a trial with Toronto FC in Canada, but failed to report.
Andrade made his debut for Portugal on 25 April 2001, playing the full 90 minutes in a 0–4 friendly defeat in France, and was part of the nation's squads at the 2002 FIFA World Cup and UEFA Euro 2004, eventually scoring three goals in 51 games. In the latter competition, played on home soil, he also put one in his own net in a 2–1 win against the Netherlands in the semi-finals. Andrade missed Portugal's fourth-place finish at the 2006 FIFA World Cup, having had knee surgery in March that year. He appeared in five matches during the Euro 2008 qualifying campaign, his last international occurring on 22 August when he started in a 1–1 draw in Armenia.
