Clerc represented Argentina for the Davis Cup from 1976 to 1989. With fellow top player Guillermo Vilas, they led Argentina to her first Davis Cup final in 1981 to set up a tie against United States in Cincinnati. After Vilas lost the first rubber in straight sets to John McEnroe, Clerc defeated Roscoe Tanner in straight sets in the second rubber to level the tie. During the third rubber, partnering Vilas, the pair lost to Fleming/McEnroe in doubles, 9–11 in the fifth and deciding set. Clerc then played McEnroe in the fourth rubber and eventually lost in 5 sets. Clerc, along with Vilas and Carlos Gattiker, made the final of 1980 World Team Cup in Düsseldorf. Clerc defeated former French Open champion Adriano Panatta 7–6, 6–3. Argentina eventually beat Italy 3–0 to claim the title. In 1981, Clerc entered the French Open off an 11-match win streak, and defeated Jimmy Connors in an epic 5-setter in the quarterfinals to extend it to 16. The streak ended when Clerc lost in 5 sets against Ivan Lendl who advanced into his first Grand Slam final, despite being up 2 sets to 1 and had a match point in the fourth set. Later that year, starting after Wimbledon, Clerc won another 28 consecutive matches before losing in the third round of the US Open. In 1982, Clerc reached the semifinals of the French Open for the second consecutive year, and was looking to create the unprecedented all-Argentine final at the French Open, but was however upset by a 17-year old Swedish teenager Mats Wilander in four sets. Wilander would go on to beat Vilas in the final in 4 sets to become the youngest winner of a Grand Slam at the time. Injuries began to plague Clerc since 1984 and his consistency dropped. Clerc never recovered and only played sporadically after 1985. He received the ATP Sportsmanship Award in 1981, and Argentine Konex Awards in 1980 and 1990 for Merit in Tennis.
Regarded as two of the most important Argentine male tennis players, José Luis Clerc and Guillermo Vilas played each other 14 times in their careers, with Vilas leading 10–4. Vilas was 6 years older than Clerc, making it a clash of generations. Vilas being a dominant force on clay for much of the second half of 1970s, Clerc was considered a rising star on clay during that time. All of their 14 meetings came after the quarterfinal stages and included 8 finals. Vilas won their first 6 encounters before 1980, including 4 finals and only lost 1 set to Clerc during that time. However, since 1980, they had a tied record of 4–4, with Clerc winning all 4 of the finals. Despite their insurmountable contribution to Argentine tennis, the pair did not get along, the tension between them even reverberating at the 2004 French Openawards ceremony, in which Vilas presented Gastón Gaudio his trophy over Clerc's objections. Coincidentally, both players' final Grand Slam appearance was at the 1989 French Open where both received a wild card entry.
Personal life
José Luis Clerc in 1980 married to Annelie Czerner and has two sons & a daughter: Juan Pablo Clerc, Dominique Clerc, and Nicolás Clerc. In 2005 they divorced, Clerc in 2008 married with Gisela Medrano MD, with whom they had a daughter named Sophie. Clerc runs a tennis school in Argentina, participates in Senior tournaments, and regularly serves as a tennis analyst for ESPN Latin America and ESPN Deportes. He also coaches Sebastian Baez, a top Argentinian junior player.