Jovan Branković was the titular Despot of Serbia from 1496 until his death in 1502. He held the title of despot given to him by Vladislas II of Hungary, and ruled a region known as Rascia, being equivalent of modern Vojvodina, under the Kingdom of Hungary. Despot Jovan was the last Serbian Despot of the Branković dynasty, which was regarded as legitimate successors of the "holy Nemanjić's", they continued the ktetorship to Hilandar and other sacred things to protect the nation and the religion. He was proclaimed a Saint in 1505, under the name Saint Despot Jovan.
Jovan was the son of Stefan Branković, despot of Serbia 1458–1459 and Saint Angelina. He ruled jointly with his brother Đorđe from 1493, and when Đorđe took monastic vows, Jovan took the throne in 1496. He had different goals to those of his brother Đorđe, Jovan did not seek to create a heavenly empire, but sought to defeat the Turks and drive them out of his lands, and as such be entitled the ranks of his ancestors. He fought successfully with the Ottoman Empire, several operations in Bosnia, especially around Zvornik. Jovan planned to free the Serbs from Ottoman rule with the help of the Republic of Venice, but he was stopped with his death in 1502. After his death, the hope of restoring Serbia under the advancing of the Ottoman Empire became weaker. He married noblewoman Jelena Jakšić, with whom he had four daughters. After his death, his wife ruled as Despotissa and then she married Ivaniš Berislavić, who was given the title despot of Serbia in 1504 by the Hungarian King. He is mentioned in the "Dell'Imperadori Constantinopolitani", or Massarelli manuscript, found in the papers of Angelo Massarelli.
He married Serbian noblewoman Jelena Jakšić, who is mentioned as “Helena, Serbiæ despotissa” in a charted dated to 1502. They had 4 children, all of whom were daughters:
Maria Magdalena, married Iwan Wiśniowiecki, a noble from Volhynia
Taking into account the dates of marriage and of bearing children of the last two daughters, researchers assume that they were daughters of the second marriage of Jelena Jaksić with Ivaniš Berislavić Some genealogies also indicate that another daughter, Milica Despina, married Neagoe Basarab, Prince of Wallachia. Some believe Milica was too old to be his daughter, but she was born cca. 1486-1488. Milica Despina might have been an illegitimate daughter of his or other close relative or even the daughter of Jovan's brother Đorđe with whom she went to Wallachia in 1503.