KIF1A


Kinesin-like protein KIF1A, also known as axonal transporter of synaptic vesicles or microtubule-based motor KIF1A, is a protein that in humans is encoded by the KIF1A gene.

Function

KIF1A is a member of the kinesin family. This protein is highly similar to mouse heavy-chain kinesin member 1A protein, which is an anterograde motor protein that transports membranous organelles along axonal microtubules. It is thought that this protein may play a critical role in the development of axonal transport neuropathies resulting from impaired axonal transport. There are multiple polyadenylation sites found in this gene. Sexual orientation has been linked to the regulatory domain of the gene.

Clinical significance

KIF1A is associated with hereditary spastic paraparesis.
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