Karlsruher SC Amateure first made an appearance in the highest league of northern Baden when it won promotion to the tier three Amateurliga Nordbaden in 1961. After two lower table results the team finished runners-up in 1964 and won the league the season after. The team continued to generally achieve good results in the league but came only ninth in 1977–78 when a top five finish was required to qualify for the new Oberliga Baden-Württemberg and instead had to enter new the tier four Verbandsliga Nordbaden. KSC Amateure finished only fifteenth in the Verbandsliga in 1979 and dropped down to the Landesliga for two seasons before returning in 1981. Between 1981and 1994 the team moved up and down between the Verbandsliga and Oberliga, earning promotion to the later in 1983, 1989 and 1994 but also being relegated again in 1985 and 1993. In between, in 1989–90, the team took out an Oberliga title but was ineligible for promotion to the 2. Bundesliga. In this era it also won the North Baden Cup on two occasions, in 1991 and 1994 and thereby advanced to the first round of the German Cup. On the first occasion it advanced to the second round where it lost to Freiburger FC while, in 1994–95, it lost to SG Wattenscheid 09 in the first round. The team entered a more successful era from 1994 onwards, now fluctuating between the Oberliga and the newly established Regionalliga Süd. KSC Amateure won the Oberliga for a second time in 1996 and earned promotion to the Regionalliga Süd, where it played for the next four seasons as a mid-table side. The team qualified for the DFB-Pokal for a third time for 1996–97 and experienced its greatest success in the competition that season when it reached the third round where it was knocked out by VfL Bochum. Despite a twelfth-place finish in 1999–2000 the team had to drop down from the Regionalliga to the Oberliga because the senior team was relegated from the 2. Bundesliga for the first time. KSC II qualified for the German Cup for the fourth and last time but was knocked out by Alemannia Aachen. Playing in the Oberliga as Karlsruher SC II while the senior side won the Regionalliga and returned to professional football the team took three seasons to recover before becoming a top side in the Oberliga again. In 2004–05, the last season it played as Karlsruher SC Amateure, the team won a third Oberliga championship and made a return to the Regionalliga Süd and played at this level for the next seven seasons until the league was disbanded in 2012. The first four seasons proved difficult for the team at this level, struggling against relegation but results greatly improved from 2009 onwards when the team earned two fifth-place finishes. Despite the fifth place in 2012 KSC II could not enter the new Regionalliga Südwest because the senior team had been relegated to the 3. Liga and reserve teams of 3. Liga clubs could not play higher than the Oberliga. From 2012 to 2018 the team played in the Oberliga Baden-Württemberg, being eligible for Regionalliga promotion once more after the senior team's promotion back to the 2. Bundesliga again. In March 2018, the club decided to close the second team for economic reasons. After fans' initiatives, KSC reopened its second team for 2019–20 and entered the Kreisklasse C, the lowest level of league football in North Baden.
The recent season-by-season performance of the club:
With the introduction of the Regionalligas in 1994 and the 3. Liga in 2008 as the new third tier, below the 2. Bundesliga, all leagues below dropped one tier. In 2012, the number of Regionalligas was increased from three to five with all Regionalliga Süd clubs except the Bavarian ones entering the new Regionalliga Südwest.
