Karyorrhexis
Karyorrhexis is the destructive fragmentation of the nucleus of a dying cell whereby its chromatin is distributed irregularly throughout the cytoplasm. It is usually preceded by pyknosis and can occur as a result of either programmed cell death, cellular senescence, or necrosis.
In apoptosis, the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases.
