Between 1877 and 1926, the club played a series of exhibition games against various Melbourne sides, including a win against a senior Hotham side that would later place third in the inaugural Victorian Football Association season. In 1926, the club was a founding member of the Keilor and Broadmeadows Football League, winning the inaugural premiership and a second grand final in 1928. In 1932, the club defected to the Essendon District Football League, but had limited success until 1968, winning its first premiership in the B Grade in a side led by player-coachNorm McKenzie. Subsequently, the club was promoted into the A Grade – now the Premier Division – where it has remained since. In 1973, the side won its first A Grade premiership, and also triumphed in first gradegrand finals in 1985, 1988, 1995, 1996, 1997, 2000 and 2001. In 2008, former and footballer Mick McGuane was appointed as senior coach. In the 2008 season, the club's A Grade, Reserves and Under-18 sides all featured in their respective grand finals at Windy Hill, with the A Grade taking out the premiership in a 33 points win over Greenvale, who had been undefeated since the 2006 preliminary final. The club's reserves side defeated West Coburg, while the under-18s side were unsuccessful in their match. With a further reserves team premiership in 2015, both the senior and reserves sides featured in grand finals – now competing in the Premier Division and Reserves Premier Division respectively. In the Premier Division final, Keilor kicked 8 goals to 3 in the opening term to defeat the Aberfeldie 13.13 to 9.8 and secure the club's 10th first grade premiership. The reserves side also prevailed, defeating Greenvale 14.8 to 10.9 to win their 11th reserves title. In 2019, for the first time in the club's history, its Premier Division side achieved both the minor premiership and the premiership, winning 20 games in a row and defeating Aberfeldie 11.9 to 10.7 in the 2019 grand final.
Women's team
In 2017, the club fielded a senior side in the inaugural Western Region and Essendon District Womens Football League season. The Blues dominated the competition, winning all 13 matches and conceding a mere 63 points, before defeating Manor Lakes by 75 points in the grand final. In 2018, the club fielded two women's teams – the EDFL Women's Premier Division side was narrowly defeated by the Sunbury Lions in the Elimination Final, while in the Northern Football Leaguethe Blues suffered a 39 point loss to Bendigo. John Tate stepped down from the role of women's coach in February 2019, and was replaced by Ron Sikora.
