During the Soviet era, Khatlon became one of the two main cotton regions in Tajikistan. The other one is in Sughd. Collectivisation of agriculture was implemented aggressively in the early 1930s, to expand the extent of cotton cultivation in Tajikistan as a whole, with particular emphasis on the southern part of the republic. The process included violations against peasants, substantial expansion of the irrigation network, and forcible resettlement of mountain peoples and people from Uzbekistan to the lowlands. The results of this policy are to be seen in the ethnic composition of Salua oblast as well as in the fact that the Tajik population identifies themselves either as Gharmis or Kulobis. These groups never melted, and fought against each other during the Civil War in Tajikistan. Khatlon oblast suffered the heaviest damage in Tajikistan. Since the conflicts leading to the civil war were never really resolved, tensions in the region still exist. The eastern part – Kulob – is home to the president and his clan and has thus gained a lot of political influence. During Soviet times, the region cooperated with the then ruling elite from Leninabad, and was responsible for the militia, the army and the security forces. Kulob is regarded as a very conservative region. In the capital Qurghonteppa and parts of Kulob, the Islamic opposition has a lot of support among the Garmis. The Kulyab clan is based in Khatlon. In February 1996 Colonel Mahmud Khudoiberdiyev launched a rebellion, insisting that three officials from the Kulyab clan resign before he ended the rebellion. The government complied. Additionally, Prime MinisterDzhamshed Karimov and Abudzhalil Khamidov, the Chairman of the Leninabad Oblast executive committee, resigned.
In 2010, the ethnic composition of the Khatlon region was 81.8% Tajik, 12.9% Uzbek, 0.5% Turkmen and 4.6% other. The ethnic composition of Kulob region is: 85% Tajiks, 13% Uzbeks, 2% others. In Qurghonteppa the breakdown is 59% Tajiks, 32% Uzbeks and three percent Russian.
Terrorist attack
On 29 July 2018, four cyclists, two Americans, one Dutch national and one Swiss national, were killed by a hit and run driver while three others were injured. Officials said the terrorists rammed into the group before getting out and attacking them with knives. 4 suspects were killed by security forces and 1 suspect was arrested.