The story takes place in Rome, ten years after the first episode, and chronicles the development of the story told in The Last Kiss: Carlo and Giulia are about to conclude their divorce, and she, having the custody of their child, has been living with a man named Simon for three years while Carlo has an affair with the twenty-five year old Anna. Paul, depressed and addicted to tranquillizers, began a relationship with Livia the wife of Hadrian, returning after serving a long sentence for attempting to import a shipment of cocaine from Colombia. Marco, apparently happily married to Veronica, actually conceals a deep crisis aggravated by the expectation of a child. Alberto, who returned from the collegiate trip with friends at the end of the first film, still wanted to get away from all that is crushing them. This situation is likely to explode for all. Carlo, despite the constant mutual betrayal, never forgot Giulia. A moment of passion will result in a new pregnancy and Anna, recognizing that the two are still in love, steps aside. Marco, irritated by the constant nights out with her girlfriends Veronica while he gets late at the office, asks her to be honest with him and not to betray him. The woman, however, starts an affair with the young artist Lorenzo. Mark, desperate and faced with the decision of Veronica to leave, is restrained by his friends from making a blunder and begins to wonder where he might have been wrong: he agrees to return and submit to the checks on his fertility which had been shown to be infertile before. Veronica discovers that she is pregnant by Lorenzo, but faced with the reaction of the immature young man who does not want to be tied down, she returns to Marco in tears asking him to forgive her. The two will welcome the child as the son who they could not have together. Since Adriano did not have a job, Carlo let him take over his shop. Later, Paul, who fell into a crisis with no way out, plays Russian roulette with the gun of his father until he loses and is shot tragically. All his friends gather at the morgue. The film ends with the image of Alberto, broken down as he had planned, arriving in Brazil in his pocket just €2,300.00 and smiles in front of the falls.
The shooting of the film began Friday, June 26, 2009 in Rome and ended Wednesday, September 30, 2009. Domenico Procacci, producer of the 2001 film, confirmed the presence of most of the cast of the first film : Stefano Accorsi, Claudio Santamaria, Sabrina Impacciatore, Pierfrancesco Field bean, Daniela Piazza, Marco Cocci and Giorgio Pasotti. He added that four new entries: Valeria Bruni Tedeschi, Adriano Giannini, Francesca Valtorta and Primo Reggiani. The role of Swabian is played by Sara Girolami. Giovanna Mezzogiorno refused to play again the role of Julia. This rejection has made Muccino angry. He said "Giovanna you can score on the agenda that will no longer work with me." While they were starting the shoot.
