Kofo was born to the family of the Lagos lawyer Omoba Eric Olawolu Moore, a member of an Egba royal family, and his wife Aida Arabella, who descended from Scipio Vaughan. She was a first cousin of Oyinkan, Lady Abayomi and a niece of Oloori Charlotte Obasa. She spent half of her young life in Lagos and the other half in U.K. Ademola was educated at C.M.S. Girls School, Lagos; Vassar College, New York; Portway College, Reading and, from 1931 to 1935, St Hugh's College, Oxford. She earned a degree in education and English from Oxford, while at Oxford she wrote a 21-page autobiography at the insistence of Margery Perham to challenge British stereotypes about Africans, she wrote of her childhood as a mixture of western cultural orientation and African orientation. She did not report overt racism while in Britain, but expressed annoyance at "being regarded as a 'curio' or some weird specimen of Nature’s product, not as an ordinary human being" and at "ineffectual remarks about our 'amazing cleverness' at being able to speak English and at being able to wear English clothes". Ademola returned to Nigeria in 1935 and took up appointment as a teacher at Queens College. While in Lagos she participated in some women organizations such as YWCA. In 1939, she married Adetokunbo Ademola, a civil servant. They had five children. As the wife of a Yoruba prince, she was entitled to the style of Oloori - and as the daughter of one, she was herself an Omoba as well - but due to the fact that her husband was also a knight, it is as Lady Ademola that she was best known. Her husband's work took the family to Warri and later to Ibadan, and Ademola established links with the women organizations in both towns. An authorized biography of Kofoworola Aina Ademola, Gbemi Rosiji's Portrait of a Pioneer, was published in 1996.
Career
While in Warri with her husband, Ademola was a member of a women's literary circle and was a teacher at Warri College. When she moved to Ibadan, she began to cultivate friendship with Elizabeth Adekogbe of the Council of Nigerian Women and Tanimowo Ogunlesi of the Women's Improvement Society. She was a member of the latter and was a bridge linking both organizations and a few others to form a collective organization. In 1958, when the NationalCouncil of Women Societies was formed she was chosen as the first president. As president, she became a board member of the International Council of Women. Ademola was also a social worker, teacher and educator, she co-founded two schools: the Girls Secondary Modern School in Lagos and New Era Girls' Secondary School, Lagos. She was a director of the board of trustees of the United Bank for Africa and secretary of the Western Region Scholarship Board. She also wrote children's books, many of them based in West African folklore, including Greedy Wife and the Magic Spoon, Ojeje Trader and the Magic Pebbles, Tutu and the Magic Gourds, and Tortoise and the Clever Ant, all part of the "Mudhut Book" series.