The Los Angeles Angels of Anaheim selected Calhoun in the eighth round of the 2010 Major League Baseball draft. He was assigned to Rookie League Orem, where in 56 games, he hit.292 with 7 HR and 42 RBI. He played 2011 with High-A Inland Empire, where in 133 games, he hit.324 with 22 HR, 99 RBI and a.957 OPS. He also stole 20 bases. He was named to the California League Postseason All-Star team as a utility player. He was the Kenny Myers Minor League Player of the Year in 2011. This monster season earned him a direct promotion to Triple-A Salt Lake to begin 2012. In 43 games prior to his first callup, he hit.296 with 5 HR and 31 RBI.
Major leagues
Los Angeles Angels
2012–2015
On May 21, 2012, Calhoun was recalled by the Angels to replace Vernon Wells, who was placed on the disabled list. He made his debut the next day, and he recorded his first major league hit the day after, a double off of Jarrod Parker. Calhoun was the 8th player from the 2010 MLB draft to make his major-league debut. He was sent back down on June 12 after 8 games with the Angels. He made the Pacific Coast League All-Star team. He had another short stint with the Angels before being called up for good in August. His final stats with the Bees in 105 games were.298 with 14 HR, 73 RBI, and a.877 OPS. He was used exclusively off the bench in August and September. In 21 games with the Angels, he hit.174 with 1 RBI in just 23 at-bats. In 2013, Calhoun was competing for the fifth outfielder spot with J. B. Shuck, but after a poor spring training, in which he hit.174 with 10 RBI and 16 strikeouts in 23 games, Shuck won the position, and Calhoun began 2013 with Salt Lake. Calhoun was recalled on July 28 to replace the injured Albert Pujols. Calhoun was hitting.354 with 12 HR and 49 RBI with Salt Lake. On August 2, Calhoun hit his first major league home run, a two-run, go-ahead shot off of Steve Delabar in the bottom of the 8th inning, part of a 4-hit night for Calhoun. Because Pujols went down, Josh Hamilton received the most time at designated hitter, leaving right field up for grabs. By the time September rolled around, Calhoun won the job, starting the last 21 games of the season there. In 58 games with the Angels in 2013, Calhoun hit.282 with 8 HR and 32 RBI. Calhoun was the starting right-fielder entering 2014. However, after just 14 games, Calhoun was placed on the disabled list with a sprained right ankle. By the time he returned on May 21, Collin Cowgill was playing well as the right-fielder, and Calhoun shared some of his starts with Cowgill. For the season, he scored 90 runs, 9th in the AL. Calhoun played in 159 games for the Angels in 2015, hitting.256 with a career high 26 HR and 83 RBI, with 164 strikeouts. He also played stellar defense in right field, posting a.989 fielding percentage and six defensive runs saved and leading the league in putouts as a right fielder en route to winning his first Rawlings Gold Glove Award.
2016–2019
Despite a slight drop-off in terms of home runs and runs batted in from 2015, Calhoun lowered his strikeout rate and walked more in the 2016 season. Altogether, Calhoun finished batting.271/.348/.438 with 5 triples, 18 home runs and 75 RBIs in 157 games played. For the third consecutive season, Calhoun played in over 150 games in 2017. He finished the season batting.244/.333/.392 with 19 home runs, 71 RBIs, and scored 77 runs. For the first half of the 2018 season, Calhoun struggled offensively despite being tied in outfield assists in MLB with 7. He was placed on the disabled list on June 3 with an oblique injury. In the second half, he hit.231 with 10 home runs. Overall, he finished the season hitting a career-low.208/.283/.369 with 19 home runs and 57 RBIs. His four double plays led AL outfielders. Calhoun began slowly in 2019, but picked it up in the second half of the season, finishing the season with a career high 33 home runs in 152 games.
Arizona Diamondbacks
On December 30, 2019, Calhoun signed a two-year contract with the Arizona Diamondbacks with a club option for the 2022 season. On July 6, 2020, it was announced that Calhoun had tested positive for COVID-19. He was cleared to resume summer training on July 10.
Personal life
Calhoun and his wife, Jennifer, welcomed a child, son Knox, in September 2016 and a daughter, Lennox, in May 2019. Calhoun grew up an Arizona Diamondbacks fan.
