The river's name comes from the Yup'ik, kusquqviim, recorded by a Russian sailor in 1826. An obsolete Tanana name for the river was Chin-ana. Upper Kuskokwim is often used to mean the people of the upper parts of the river, while Yup'ik people live along the lower river.
Course
The river is formed by the confluence of East Fork Kuskokwim River and North Fork Kuskokwim River, east of Medfra. From there it flows southwest to Kuskokwim Bay and the Bering Sea. The Kuskokwim is fed by several forks in central and south-central Alaska. The North Fork rises in the Kuskokwim Mountains approximately 200 miles WSW of Fairbanks and flows southwest in a broad valley. The South Fork rises in the southwestern end of the Alaska Range west of Mount Gerdine and flows north-northwest through the mountains, past Nikolai, receiving other streams that descend from the Alaska Range northwest of Denali. The two forks join near Medfra, and from there the main stem of the Kuskokwim flows southwest, past McGrath, in a remote valley between the Kuskokwim Mountains to the north and the Alaska Range to the south. In southwest Alaska the river emerges from the Kuskokwim Mountains in a vast lake-studded alluvial plain south of the Yukon River, surrounded by vast spruce forests. It passes a series of Yup'ik villages, including Aniak, and approaches within 50 mi of the Yukon before diverging southwest. Southwest of Bethel, the largest community on the river, it broadens into a wide marshy delta that enters Kuskokwim Bay approximately 50 mi SSW of Bethel. The lower river below Aniak is located within the Yukon Delta National Wildlife Refuge. The river receives the Big Riverfrom the south approximately 20 miles southwest of Medfra. It receives the Swift, Stony, and Holitna rivers from the south at the southern end of the Kuskokwim Mountains before emerging on the coastal plain. It receives the Aniak River from the south at Aniak. Approximately 20 miles upstream from Bethel it receives the Kisaralik and Kwethluk rivers from the south. It receives the Eek River from the east at Eek near its mouth on Kuskokwim Bay.
History
The principal economic activities along the river have historically been fur trapping and fishing. Subsistence fishing for salmon and whitefish provides a staple of the Yup'ik diet along the river. Economic deposits of placer gold were discovered in 1901 near Aniak. Mineral production in the region has mainly been from scattered placer gold deposits that through 2004 had produced a total of 3.5 million troy ounces of gold. The primary route of the Iditarod Trail follows the South Fork Kuskokwim River out of the Alaska Range and crosses the main stem of the river near McGrath.