Kwame

• Kwame
• Kwame Alexander, American author
• Kwame Anthony Appiah, a Ghanaian-British philosopher of semantics and racism
• Kwame Awuah, Canadian soccer player
• Kwame Brown, American former basketball player
• Kwame Dawes, Ghanaian poet currently living in America, managing editor of the Prairie Schooner literary journal
• Kwame Harris, former American football player
• Kwamé Holland, an American rapper who enjoyed brief popularity during the golden age of hip hop, reemerged as a music producer named K1 Million
• Kwame Holman, American producer, correspondent, and congressional correspondent
• Kwame Kenyatta, an American politician
• Kwame Kilpatrick, former mayor of Detroit, Michigan
• Kwame Nkrumah, a Ghanaian politician and one of the founders of Pan-Africanism
• Kwame Raoul, a Democratic member of the Illinois Senate, representing the 13th district since 2004
• Kwame Somburu, an American socialist political activist
• Kwame Tucker, a Bermudian cricketer
• Kwame Ture, a Trinidadian-American black activist and leader of the Student Nonviolent Coordinating Committee and the Black Panther Party
• Kwamena Bartels, a Ghanaian politician and former government minister of the New Patriotic Party
• Kwamena Ahwoi, a Ghanaian politician who served as Minister for Local Government and Rural Development from 1990 to 2001 and Minister of Foreign Affairs in 1997
• Kwamina Ropapa Mensah, a Ghanaian footballer who plays for Nashville SC in the USL Championship
• Osei Kwame Panyin, eighteenth-century leader of the Ashanti Confederacy, in what is southern and central Ghana today
• Rich Kwame Amevor, Australian rapper

  Fictional character

• Kwame, a fictional character in the animated television series Captain Planet and the Planeteers