Kynurenine—oxoglutarate transaminase
In enzymology, a kynurenine-oxoglutarate transaminase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are L-kynurenine and 2-oxoglutarate, whereas its two products are 4--2,4-dioxobutanoate and L-glutamate. The former product is an unstable α-oxo acid that quickly undergoes intramolecular cyclization to form kynurenic acid.
This enzyme belongs to the family of transferases, to be specific, the transaminases, that transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:2-oxoglutarate aminotransferase. Other names in common use include kynurenine transaminase , kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, and L-kynurenine aminotransferase. This enzyme participates in tryptophan metabolism. It employs one cofactor, pyridoxal phosphate.
KYAT1, AADAT, and KYAT3 are examples of enzymes of this class. GOT2 is also believed to catalyze the above reaction.As of early 2009, 18 structures have been solved for this class of enzymes, with PDB accession codes,, ,,,,,,,,,,,,,,, and.
