LMO2


LIM domain only 2, also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.

Function

LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

Clinical significance

The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster, where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.

Interactions

LMO2 has been shown to interact with: