LRRC7


Leucine rich repeat containing 7 also known as LRRC7, Densin-180, or LAP1 is a protein which in humans is encoded by the LRRC7 gene.

Structure

Found to be densely associated to the postsynaptic density, it has been characterised as a 188 kDa, 1495 residues long, brain-specific protein containing 16 leucine-rich repeats within the 500 N-terminal residues, and one Psd95/Discs large/Zona occludens domain within the 200 C-terminal residues. Originally postulated to have an apparent transmembrane domain, it has now been shown that the protein has numerous phosphorylation sites both N- and C-term of this domain, and that protein is therefore cytoplasmic; palmitoylation is thought to occur near the N-terminus of the protein which would account for localisation of the protein at the PSD.

Interactions

LRRC7 has been shown to interact with CDH2.
The currently exposed interactions of Densin-180 portray the protein as a promiscuous player amongst key synaptic players, fitting with the original observation of the protein’s dense presence among core PSD proteins by Mary B. Kennedy's Laboratory. Identified interaction partners include: CaMKII-alpha, alpha-Actinin and NR2B, Cav1.3 channels, MAGUIN-1, Shank, PSD-95, beta-Catenin, delta-Catenins and NCadherin. The nature and function of these interactions, detailed in tables 1-1 and 1-2, portray Densin-180 as a key interactor in the midst of receptor proteins, scaffolding proteins and structural proteins.
It is also quite possible that Densin-180 dimerises or multimerises through interactions between its PDZ domain and its own terminal amino acid residues.