Based on the 2007 national census conducted by the Central Statistical Agency of Ethiopia, the woreda has a total population of 72,625, an increase of 16.67% over the 1994 census, of whom 36,203 are men and 36,422 women; the census reported no urban inhabitants. With an area of 1,873.35 square kilometers, La'ilay Maychew has a population density of 38.77, which is less than the Zone average of 56.29 persons per square kilometer. A total of 14,698 households were counted in this woreda, resulting in an average of 4.94 persons to a household, and 14,203 housing units. The majority of the inhabitants said they practiced Ethiopian Orthodox Christianity, with 99.29% reporting that as their religion. The 1994 national census reported a total population for this woreda of 90,123, of whom 43,927 were men and 46,196 were women; 27,973 or 31.04% of its population were urban dwellers. The largest ethnic group reported in La'ilay Maychew was the Tigrayan. Tigrinya was spoken as a first language by 99.58%. 95.15% of the population practiced Ethiopian Orthodox Christianity, and 4.75% were Muslim. Concerning education, 25.61% of the population were considered literate, which is more than the Zone average of 14.21%; 34.67% of children aged 7-12 were in primary school; 7.44% of the children aged 13-14 were in junior secondary school, and 8.7% of the inhabitants aged 15-18 were in senior secondary school. Concerning sanitary conditions, about 75% of the urban houses and 30% of all houses had access to safe drinking water at the time of the census; 39% of the urban and 16% of the total had toilet facilities.
Agriculture
A sample enumeration performed by the CSA in 2001 interviewed 15,093 farmers in this woreda, who held an average of 1.1 hectares of land. Of the 16,536 hectares of private land surveyed, 93.25% was in cultivation, 0.68% pasture, 3.37% fallow, 0.27% woodland, and 2.43% was devoted to other uses. For the land under cultivation in this woreda, 70.62% was planted in cereals, 21.6% in pulses, 0.79% in oilseeds, and 0.07% in vegetables. The area planted in fruit trees was 10 hectares and 11 hectares in gesho. 78.26% of the farmers both raised crops and livestock, while 21% only grew crops and 0.74% only raised livestock. Land tenure in this woreda is distributed amongst 82.12% owning their land, 17.43% renting, and 0.44% other forms of tenure.