The construction of the school began on March 16, 1985. During this time, Kindergarten to Fourth Grade classes were temporarily held first at La Salle Green Hills. Construction was delayed because of the costs and logistics that were involved in building a school on a mountain. Classes were finally transferred to the Antipolo campus on January 13, 1986 and were housed in two buildings. A third building was completed in the summer of 1987, with a fourth one completed in 1989. The school's St. Benilde Multi-purpose Hall was finished in 1991, while the high school and laboratory-library buildings were completed in 1994. The Tertiary Education Unit was launched in 1998, with BS in Elementary Education and BS in Accountancy as the pioneer offerings. In 2006, La Salle College became part of De La Salle Philippines, Inc. In 2014, De La Salle–College of Saint Benilde acquired a building in the city proper for the Tertiary Education Unit of La Salle College Antipolo. La Salle College celebrated its 30th anniversary last 2016. The senior high school also opened during this year. In 2018, the Tertiary Education unit of La Salle College Antipolo merged with De La Salle-College of Saint Benilde following Benilde's construction of a multistorey building in the city proper of Antipolo. The campus is called DLS-CSB - Antipolo. With the college department spun off, La Salle College Antipolo focused on providing basic education from kindergarten to senior high school. In 2019, LSCA opened the Pre-School campus at the town proper of Antipolo City offering Nursery 1, Nursery 2, and Kindergarten. The campus is situated along Sen. L. Sumulong St. Bragy. San Jose Antipolo City.
Academics
At present LSCA offers Pre-School to Senior High School programs. Senior High School Program:
La Salle College Antipolo's sports teams are called Voyagers. The official colors are green and white. The college has varsity teams for basketball, football, baseball, taekwondo, badminton, handball, volleyball, and table tennis.
The program had captured back-to-back WNCAA titles for badminton junior's division in 2006–2008. The football boys' grade school team had won the DLSZ Football Fiesta championship in 2007. The team also took home the championship in the 2007 CALABARZON regional championship.
The taekwondo, volleyball, futsal and girls' basketball teams had won 2nd runner-up finishes in the 38th season of the WNCAA. Meanwhile, the table tennis team took home the 1st runner-up title of the WNCAA in 2006.
The badminton team also took home championships in Toby's and Yonex badminton tourneys.
