Laboratory Response Network


The Laboratory Response Network is a collaborative effort within the US federal government involving the Association of Public Health Laboratories and the Centers for Disease Control and Prevention. Most state public health laboratories participate as reference laboratories of the LRN. These facilities support hundreds of sentinel laboratories in local hospitals throughout the United States and can provide sophisticated confirmatory diagnosis and typing of biological agents that may be used in a bioterrorist attack or other bio-agent incident. The LRN was established in 1999.

Levels

The LRN consists of a loose network of government labs at three levels:

Sentinel Laboratories

These laboratories, found in many hospitals and local public health facilities, have the ability to rule out specific bioterrorism threat agents, to handle specimens safely, and to forward specimens to higher-level labs within the network.

National Laboratories

These laboratories, including those at CDC and U.S. Army Medical Research Institute of Infectious Diseases, can use BSL-4 practices and serve as the final authority in the evaluation of potential bioterrorism specimens. They provide specialized reagents to lower level laboratories and have the ability to bank specimens, perform serotyping, and detect genetic recombinants and chimeras.