On his return to Russia, Blumentrost was appointed personal physician to Princess Natalia, Tsar Alexis's daughter and Tsar Peter the Great's sister. He continued his studies in Paris and Amsterdam. After his return to St. Petersburg, Peter the Great sent him to the Olonets Governorate to study the Marcial mineral springs in Kondopozhsky District. When Robert Erskine, the Tsar's Scottish-born personal physician, died in 1718, Blumentrost was appointed to the position. He kept Johann Daniel Schumacher, Erskine's assistant who had studied at the University of Strasbourg and had been in charge of the Imperial Library and the Kunstkamera under Erskine, on as his secretary.
In 1724, on the Tsar's orders, he founded the SaintPetersburg Academy of Sciences. The first session was held after Peter's death, on November 12, 1725, and it opened officially in December with Blumentrost as its first president. Most of the members were recruited abroad; with the assistance of the philosopher Christian Wolff, he successfully invited the Bernoulli brothers Nicholas and Daniel, Christian Goldbach, physician Georg Bilfinger, astronomer and geographer Joseph De L’Isle and historian Gerhard Müller, among others. In 1727 Leonhard Euler joined the Academy at Blumentrost's invitation in a letter sent via Daniel Bernoulli. He remained president of the Academy under Empress Catherine I; when she was succeeded by Peter II, he followed the court to Moscow in 1728, after signing an order under which Schumacher was left in charge of the Academy, with three academicians appointed to 4-month terms as his deputies. This led to discord among the members. After the Tsar's death, Blumentrost lost his influence. Nicolaas Bidloo did not approve of his treatment methods and he did not dare appear before the new Empress, Anna. He remained president of the Academy until 1733 and returned to St. Petersburg, where he lived in the palace of the Empress' sister, Catherine Ivanovna, Duchess of Mecklenburg.
Retirement and death
The Duchess of Mecklenburg died on June 14, 1733. The Empress ordered an investigation of Blumentrost; no fault was found on his part, but by 19 June he had been stripped of his positions and income and expelled from St. Petersburg. For a few years he lived in Moscow and had a private medical practice. In 1738, under the patronage of archiaterJohann Bernhard Fischer, he became head physician at the Moscow military hospital and director of the hospital school. Empress Anna did not trust Blumentrost, mainly because of his devotion to the two daughters of Peter the Great and Catherine, Anna and Elizabeth. When Elizabeth became Empress, he came back into royal favour. She reinstated his rank of State Councillor and raised his salary. In 1754 he was appointed curator of the newly opened University of Moscow. Blumentrost died in St. Petersburg on 27 March 1755 of hydrothorax. He is buried at the church of St. Sampson the Hospitable, now Saint Sampson's Cathedral. Blumentrost's brothers Ivan and Christian were also court physicians. Ivan was also personal physician to Peter I and had also studied in Halle and Leiden. He fell out of favour under Empress Anna and died in poverty in 1756; he is buried in the same grave with Laurentius.