He made his debut at the Comédie-Française on 14 September 1750 in the role of Titus in Voltaire's Brutus and performed Seïde in Voltaire's Mahomet on 30 September. Owing to the hostility of the actors it was only after a struggle of seventeen months that, by the command of King Louis XV he was accepted at the Comédie-Française. He had performed the leading role of Orosmane at court in Voltaire's Zaïre, causing Louis XV to declare: "He made me weep, and I never weep." Lekain was made a member of the company on a trial basis at a salary of 12,000 livres per year on 4 January 1751 and was received definitively on 8 February 1752. His success was immediate. Among his best parts were Herod the Great in Mariamne, Nero in Britannicus and similar tragic roles, in spite of the fact that he was short, stout, and lacking in good looks.
Reforms
His name is connected with several important scenic reforms. It was the practice in most theatres at the time for seating to be placed on the stage, and this was also true at the theatre of the Comédie-Française, the Salle de la rue des Fossés-Saint-Germain-des-Prés. High-priced tickets were sold to privileged spectators, who wanted to be seen but, as a consequence, obstructed the use of realistic scenery. Lekain and Diderot advocated for the actors to remove them; in 1759 Count Lauragais paid the excessive indemnity the actors demanded to compensate for the loss in revenue. Lekain also protested against the method of sing-song declamation which was prevalent, and endeavoured to correct the costuming of the plays, although unable to obtain the historical accuracy that François Joseph Talma sought.
Marriage
Lekain married Christine-Charlotte-Josèphe Sirot on 28 July 1750. His wife made her debut at the Comédie-Française in March 1757 and was received on a trial basis on 25 April, and definitively in 1761. She retired with a pension of 1,000 livres in 1767 and died on 18 August 1775.
Death
Lekain died in Paris and was survived by two sons, Bernardin and Louis-Théodore. His older son published his Mémoires with his correspondence with Voltaire, David Garrick and others. They were reprinted in Mémoires sur l'art dramatique.