Born in Hong Kong on 21 September 1891, he was the son of a wealthy local businessman, Li Shek-pang. He was educated at the Queen's College and graduated with a Bachelor of Arts from the University of Hong Kong in 1916 as one of its first graduates. After his education, Li entered into his father's rice business, the Nam Wo Hong and also his shipping business. When in 1917 the Hong Kong government announced the restriction of the use of vessels during the First World War, Li organised the local merchants to demand for the exemption of commercial vessels. In November 1918, Li co-founded the Bank of East Asia with Fung Ping-shan, Kan Tung-po and his brother Li Koon-chun. Li Tse-fong became the bank's assistant manager, manager and later life director. He was also director of the China Emporium, China Provident Co., Ltd., Green Island Cement Co., Ltd., A. S. Watson Co, Ltd. and various public companies.
Public service
Li appointed to the Currency Committee in 1930, which laid the foundation of introducing the Hong Kong Dollar,. He was later appointed to various public offices including the Board of Education from 1935, member of the Court of the University of Hong Kong from 1936, the Committee on the Training of Teachers Training of Teachers in 1938, and the War Revenue Committee in 1940. Li was appointed to the Urban Council in 1939 in succession of W. N. T. Tam and was appointed member of the Legislative Council temporarily in 1939 during the absence of Li Shu-fan and again in 1941 before the Japanese invasion of Hong Kong. He was also Chairman of the Tung Wah Hospital and Po Leung Kuk, the two largest charities in Hong Kong at the time. During the Japanese occupation of Hong Kong, he was appointed by the Japanese to the Chinese Representative Council and the Chinese Cooperative Council. In 1944, when the Japanese were losing the war, Li avoided their duties from the two Councils by withdrawing from the public life. Due to accusations of his collaboration with the Japanese, he was not reappointed to the Legislative Council after the war. A post-war British military administration was set up with Brigadier David M. MacDougall as Chief Civil Affairs Officer, who explained why men like Li Tse-fong were not reappointed after the war: "Hong Kong was set to make a fresh start, if such was possible. Li Tse-fong... who in a real sense bore the burden and the heat of Japanese occupation had thereby inevitably become controversial figures, innocent though they were of any taint of collaboration."
** Sixth son: Li Fook-pui, Manager of the Insurance branch of the Swire Group
Legacy
Hong Kong Sheng Kung Hui North Point St. Peter's Church was originally envisioned by Li in 1950 and when construction was completed in 1962, the church was dedicated to the memory of Li Tse-fong and Tang Sau-hing
LI Tze Fong Memorial Scholarship awards were endowed in 1998 to the glory of God and in memory of Li Tze Fong. The fellowships are open to outstanding graduates from any institution and country and are for full-time study and research leading to a master or doctorate degree at the University of British Columbia. The fellowships are open to candidates in any field of study which is offered at the University. Candidates are selected from applicants for University Graduate Fellowships. Recipients are known as Li Tze Fong Scholars.