Lane was ordained in the Church of England as a deacon in 1993 and as a priest in 1994. She served her curacy at St James's Church, Blackburn, from 1993 to 1996. She served in the Diocese of Chester from 2000 to 2014 and was the vicar of the combined benefice of St Peter's Hale and St Elizabeth's Ashley from 2007. She was also the Dean of Women in Ministry in the diocese from 2010. In 2013, Lane was elected one of eight participant observers of the House of Bishops as the observer representing the North West of England. The observers were senior female priests who would attend and participate in meetings of the House of Bishops until six women had full membership of the house. She attended her first meeting in December 2013. Lane ceased to be an observer when she was elected, by and from among the suffragan bishops of the Province of York, to the House of Bishops in 2015. As an elected suffragan and later a diocesan bishop, she has been a full member of the house since 2015.
Episcopate
On 17 December 2014, it was announced that Lane was to become the Bishop of Stockport, a suffragan bishop in the Diocese of Chester. The British prime minister, David Cameron, called her appointment "historic" and "an important step forward for the Church towards greater equality in its senior positions". She was consecrated at York Minster on 26 January 2015 by John Sentamu, Archbishop of York. When the archbishop asked the congregation if Lane should be consecrated as a bishop the service was briefly interrupted by a vexatious litigant and Anglo-Catholic priest, Paul Williamson, who exclaimed "It's not in the Bible" and called Lane's being a woman an "absolute impediment". There was no opposition when Sentamu, having carefully explained the legality of the act, asked a second time. One of the first duties that Lane undertook as a bishop was her involvement in the consecration service for Philip North as the Bishop of Burnley on 2 February 2015. North is a traditionalist Anglo-Catholic who does not accept the ordination of women. Therefore, Lane and all but three other bishops did not take part in the laying on of hands. Instead, they gathered in prayer around North with only the three bishops "who share his theological conviction regarding the ordination of women" laying their hands on him. She was installed at Chester Cathedral on 8 March 2015, International Women's Day, signalling the official start of her ministry as Bishop of Stockport. On 18 December 2018, it was announced that Lane was to become the eighth Bishop of Derby, succeeding Alastair Redfern; she grew up in the diocese, in Glossop. The confirmation of her canonical election took place on 11 February 2019, at which point she legally became the Bishop of Derby. The Diocese of Derby is the first Church of England diocese to have a woman diocesan bishop and a woman suffragan bishop. She was installed at Derby Cathedral on 25 May 2019. She was introduced as a Lord Spiritual at the House of Lords by the Archbishop of Canterbury and the Archbishop of York on 2 July 2019.
Personal life
Lane married her husband, George Lane, in 1990. They had met while both students at St Peter's College, Oxford, in the late 1980s. He is an Anglican priest and currently the co-ordinating chaplain at Manchester Airport. They were among the first married couples to be ordained at the same time in the Church of England. They have two children, Connie and Benedict.