In 1985, Grant returned to England and became a journalist, working for The Guardian, and eventually wrote her own column for eighteen months. She published her first book, a non-fiction work, Sexing the Millennium: A Political History of the Sexual Revolution, in 1993. She wrote a personal memoir of her mother's fight with vascular dementia called Remind Me Who I Am, Again, which was cited in a discussion about ageing on BBC Radio 4's Thinking Allowed in December 2003. Her fiction draws heavily on her Jewish background, family history, and the history of Liverpool. In an interview by Emma Parker for the University of Leicester's July 2008 'Unsettling Women: Contemporary Women's Writing and Diaspora' conference, and later published in the journal Wasafiri, Grant said:
"I always wanted to make my living as a writer, but you couldn’t get a job as an author, so I got a job as a reporter on a local paper just before my eighteenth birthday. I always knew that sooner or later I would write fiction, although I didn’t realise it would be as late as it was. I didn’t write a novel until after the age of forty because it took me a long time to find a fictional voice, which was to do with being Jewish. I had been trying different voices and found none adequate. I felt that there were two modes open to me. One was to have a voice like Howard Jacobson, which is absolutely embedded within a recognisable Jewish community, but I was from a community which was not recognised as Jewish. People say, ‘Oh, I never knew that there were any Jews in Liverpool’. Also, growing up in a middle-class family made me marginal to the Liverpool voice, which had always been working-class or Irish. And then there was the generalised middle-class English voice, which always felt to me like ventriloquism. And I didn’t feel that I could write like an American Jewish author such as Philip Roth, who shows how Jewish Americans, like Irish Americans and Italian Americans, have contributed to American national identity, because by the time the Jews arrived here, British national identity had already been formed. And that’s why my first novel, The Cast Iron Shore, is about somebody who feels marginal. It was only when I started writing about people who are marginal, who have problematic identities and problems with belonging, that I found my voice."
Grant's choices of her favourite pieces of classical music were broadcast as part of BBC Radio 3's Saturday Classics in June 2012. In November 2016, The Guardian newspaper published a detailed account of Grant's writing process, in which she noted, "My rituals of writing are so calcified I could be an elderly colonel at his gentleman's club: ironed newspaper, tea piping hot, shoes the correct colour for in town. Without the scaffolding of my habits, I'm superstitiously convinced I'd never write a word. I don't – can't – write after lunch, in a cafe or any other public place, including trains and planes, or when anyone else is in the house. It's an act of severe, intense solitude, partly now destroyed by the internet, and its deceptive promise of the ease of looking things up as you go along."
Non fiction
Sexing the Millennium: A Political History of the Sexual Revolution. HarperCollins 1993