| Rank | Title | Studio | Actor | Director | Gross |
| 1. | Spider-Man | Columbia Pictures | Tobey Maguire, Willem Dafoe, Kirsten Dunst, James Franco, Cliff Robertson and Rosemary Harris | Sam Raimi | $403,706,375 |
| 2. | ' | 20th Century Fox | Ewan McGregor, Natalie Portman, Hayden Christensen, Ian McDiarmid, Samuel L. Jackson, Christopher Lee, Anthony Daniels, Kenny Baker and Frank Oz | George Lucas | $302,191,252 |
| 3. | Harry Potter and the Chamber of Secrets | Warner Bros. Pictures | Daniel Radcliffe, Rupert Grint, Emma Watson, Kenneth Branagh, John Cleese, Robbie Coltrane, Warwick Davis, Richard Griffiths, Richard Harris, Jason Isaacs, Alan Rickman, Fiona Shaw, Maggie Smith and Julie Walters | Chris Columbus | $243,867,371 |
| 4. | Signs | Walt Disney Studios | Mel Gibson, Joaquin Phoenix, Rory Culkin and Abigail Breslin | M. Night Shyamalan | $227,486,621 |
| 5. | My Big Fat Greek Wedding | IFC Films | Nia Vardalos, John Corbett, Lainie Kazan, Michael Constantine, Gia Carides, Louis Mandylor, Andrea Martin and Joey Fatone | Joel Zwick | $223,900,343 |
| 6. | ' | New Line Cinema | Elijah Wood, Ian McKellen, Liv Tyler, Viggo Mortensen, Sean Astin, Cate Blanchett, John Rhys-Davies, Bernard Hill, Christopher Lee, Billy Boyd, Dominic Monaghan, Orlando Bloom, Hugo Weaving, Miranda Otto, David Wenham, Brad Dourif, Sean Bean and Andy Serkis | Peter Jackson | $218,595,905 |
| 7. | Austin Powers in Goldmember | New Line Cinema | Mike Myers, Beyoncé Knowles, Seth Green, Michael York, Robert Wagner, Mindy Sterling, Verne Troyer and Michael Caine | Jay Roach | $212,864,437 |
| 8. | Men in Black II | Columbia Pictures | Tommy Lee Jones, Will Smith, Lara Flynn Boyle, Johnny Knoxville, Rosario Dawson, Tony Shalhoub and Rip Torn | Barry Sonnenfeld | $190,418,803 |
| 9. | Ice Age | 20th Century Fox | voices of Denis Leary, John Leguizamo and Ray Romano | Chris Wedge | $176,387,405 |
| 10. | A Beautiful Mind | Universal Pictures | Russell Crowe, Ed Harris, Jennifer Connelly, Paul Bettany, Adam Goldberg, Judd Hirsch, Josh Lucas, Anthony Rapp and Christopher Plummer | Ron Howard | $154,865,545 |
