| # | Date | Film | Gross | Openings in the top ten |
| 1 | | Night at the Museum | $2,167,918 | Stormbreaker, ' |
| 2 | | Rocky Balboa | $1,609,380 | The Holiday, Fuera del cielo |
| 3 | | ' | $1,559,476 | |
| 4 | | Apocalypto | $2,365,480 | Dreamgirls |
| 5 | | Kilómetro 31 | $1,508,862 | The Pursuit of Happyness |
| 6 | | Kilómetro 31 | $1,468,895 | Blood Diamond, Employee of the Month |
| 7 | | Ghost Rider | $2,050,782 | Morirse en domingo, Combien tu m'aimes? |
| 8 | | Norbit | $1,246,087 | Notes on a Scandal |
| 9 | | Norbit | $773,988 | ', Freedom Writers |
| 10 | | Niñas Mal | $1,602,673 | Music and Lyrics, The Fountain |
| 11 | | Epic Movie | $1,364,983 | Arthur and the Invisibles, The Good Shepherd |
| 12 | | 300 | $2,585,419 | |
| 13 | | Meet the Robinsons | $1,877,402 | Shooter, Cuando las cosas suceden, Alatriste, The Hills Have Eyes 2 |
| 14 | | Wild Hogs | $1,329,865 | The Reaping, Mr. Bean's Holiday, TMNT, Are We Done Yet?, The Queen |
| 15 | | Wild Hogs | $1,026,207 | ', The Number 23 |
| 16 | | Perfect Stranger | $940,938 | Disturbia, Happily N'Ever After, Primeval |
| 17 | | The Messengers | $674,664 | |
| 18 | | Spider-Man 3 | $12,002,306 | An American Haunting |
| 19 | | Spider-Man 3 | $6,118,161 | The Invisible, Blades of Glory |
| 20 | | Spider-Man 3 | $2,997,567 | Premonition |
| 21 | | ' | $8,868,597 | |
| 22 | | Pirates of the Caribbean: At World's End | $7,232,827 | 28 Weeks Later, Zodiac, My First Wedding |
| 23 | | Pirates of the Caribbean: At World's End | $5,146,385 | Fracture |
| 24 | | Shrek the Third | $9,117,354 | |
| 25 | | ' | $5,676,476 | |
| 26 | | Fantastic Four: Rise of the Silver Surfer | $3,143,520 | Ocean's Thirteen |
| 27 | | Ratatouille | $4,607,814 | Live Free or Die Hard, Griffin & Phoenix |
| 28 | | Harry Potter and the Order of the Phoenix | $7,852,698 | ', |
| 29 | | Transformers | $5,457,346 | Lonely Hearts |
| 30 | | Transformers | $3,048,772 | No Reservations, Whisper, La Niña en la piedra, Hostel Part II |
| 31 | | The Simpsons Movie | $5,457,104 | Evan Almighty, Alpha Dog |
| 32 | | The Simpsons Movie | $1,951,146 | Surf's Up, License to Wed, Hairspray, Mr. Brooks |
| 33 | | The Simpsons Movie | $883,439 | Next, El Búfalo de la Noche, Vacancy |
| 34 | | Surf's Up | $620,760 | Knocked Up, Breach |
| 35 | | Rush Hour 3 | $1,056,839 | |
| 36 | | The Bourne Ultimatum | $1,452,371 | Stardust |
| 37 | | Stardust | $790,715 | Bratz |
| 38 | | ' | $2,151,235 | Underdog |
| 39 | | I Now Pronounce You Chuck and Larry | $1,249,268 | The Invasion |
| 40 | | I Now Pronounce You Chuck and Larry | $986,395 | Superbad, Catacombs, A Mighty Heart |
| 41 | | The Game Plan | $1,915,281 | The Brave One, Bad Habits |
| 42 | | The Game Plan | $1,308,059 | ', Hasta el viento tiene miedo, Michael Clayton, ' |
| 43 | | The Game Plan | $905,474 | 1408, Because I Said So, The Kingdom, Saw IV |
| 44 | | La Leyenda de la Nahuala | $1,479,685 | The Heartbreak Kid, Halloween |
| 45 | | Bridge to Terabithia | $958,958 | Lions for Lambs, Cascia |
| 46 | | Bridge to Teribathia | $798,273 | Hannibal Rising, ', Good Luck Chuck |
| 47 | | Beowulf | $1,931,957 | Dead Silence, Rendition |
| 48 | | Bee Movie | $2,600,799 | Hitman, 30 Days of Night |
| 49 | | Bee Movie | $1,624,652 | Fred Claus |
| 50 | | Enchanted | $2,761,545 | The Golden Compass, P2 |
| 51 | | Alvin and the Chipmunks | $1,651,829 | Sultanes del Sur |
| 52 | | ' | $2,397,296 | , Love in the Time of Cholera, Things We Lost in the Fire |
