List of 2008 box office number-one films in the United Kingdom
This is a list of films which have placed number one at the weekend box office in the United Kingdom during 2008.
| # | Weekend End Date | Film | Total Weekend Gross | Reference |
| 1 | 6 January 2008 | I Am Legend | £3,740,369 | |
| 2 | 13 January 2008 | I Am Legend | £2,051,372 | |
| 3 | 20 January 2008 | ' | £1,970,363 | |
| 4 | 27 January 2008 | ' | £4,525,246 | |
| 5 | 3 February 2008 | Cloverfield | £3,485,956 | |
| 6 | 10 February 2008 | ' | £2,483,297 | |
| 7 | 17 February 2008 | Jumper | £3,068,803 | |
| 8 | 24 February 2008 | Jumper | £1,513,088 | |
| 9 | 2 March 2008 | The Bank Job | £951,013 | |
| 10 | 9 March 2008 | Vantage Point | £1,454,636 | |
| 11 | 16 March 2008 | 10,000 BC | £1,932,539 | |
| 12 | 23 March 2008 | Horton Hears a Who! | £2,947,089 | |
| 13 | 30 March 2008 | 27 Dresses | £1,752,897 | |
| 14 | 6 April 2008 | 27 Dresses | £1,028,661 | |
| 15 | 13 April 2008 | 21 | £1,649,855 | |
| 16 | 20 April 2008 | 21 | £1,010,923 | |
| 17 | 27 April 2008 | Forgetting Sarah Marshall | £2,144,038 | |
| 18 | 4 May 2008 | Iron Man | £5,465,103 | |
| 19 | 11 May 2008 | Iron Man | £1,976,721 | |
| 20 | 18 May 2008 | Iron Man | £1,917,925 | |
| 21 | 25 May 2008 | Indiana Jones and the Kingdom of the Crystal Skull | £12,227,799 | |
| 22 | 1 June 2008 | ' | £8,767,265 | |
| 23 | 8 June 2008 | ' | £3,085,231 | |
| 24 | 15 June 2008 | The Incredible Hulk | £3,253,723 | |
| 25 | 22 June 2008 | The Incredible Hulk | £1,870,800 | |
| 26 | 29 June 2008 | ' | £4,060,532 | |
| 27 | 6 July 2008 | Hancock | £9,589,095 | |
| 28 | 13 July 2008 | Mamma Mia! The Movie | £6,594,058 | |
| 29 | 20 July 2008 | Mamma Mia! The Movie | £4,561,109 | |
| 30 | 27 July 2008 | The Dark Knight | £11,191,824 | |
| 31 | 3 August 2008 | The Dark Knight | £6,737,306 | |
| 32 | 10 August 2008 | ' | £4,434,650 | |
| 33 | 17 August 2008 | The Dark Knight | £2,302,866 | |
| 34 | 24 August 2008 | ' | £2,969,602 | |
| 35 | 31 August 2008 | Step Brothers | £1,681,492 | |
| 36 | 7 September 2008 | RocknRolla | £1,565,438 | |
| 37 | 14 September 2008 | Pineapple Express | £1,372,911 | |
| 38 | 21 September 2008 | Tropic Thunder | £2,483,271 | |
| 39 | 28 September 2008 | Tropic Thunder | £1,345,392 | |
| 40 | 5 October 2008 | How to Lose Friends & Alienate People | £1,154,607 | |
| 41 | 12 October 2008 | The House Bunny | £894,188 | |
| 42 | 19 October 2008 | Burn After Reading | £2,045,565 | |
| 43 | 26 October 2008 | ' | £8,409,375 | |
| 44 | 2 November 2008 | Quantum of Solace | £15,384,217 | |
| 45 | 9 November 2008 | Quantum of Solace | £9,221,744 | |
| 46 | 16 November 2008 | Quantum of Solace | £5,164,182 | |
| 47 | 23 November 2008 | Quantum of Solace | £2,884,789 | |
| 48 | 30 November 2008 | Four Christmases | £2,275,585 | |
| 49 | 7 December 2008 | ' | £6,342,997 | |
| 50 | 14 December 2008 | The Day the Earth Stood Still | £2,752,132 | |
| 51 | 21 December 2008 | Twilight | £2,508,422 | |
| 52 | 28 December 2008 | Yes Man | £2,331,490 |