List of 2010 box office number-one films in the Philippines
This is a list of films which placed number one at the weekend box office for the year 2010 in the Philippines.
| # | Date | Film | Gross | Gross | Notes |
| 1 | Avatar | $203,086 | ₱9,390,697 | It was Avatar third week at number one. | |
| 2 | Avatar | $684,360 | ₱31,234,190 | ||
| 3 | Avatar | $690,169 | ₱30,931,304 | ||
| 4 | Avatar | $521,796 | ₱24,133,065 | ||
| 5 | Paano Na Kaya* | $890,381 | ₱41,410,374 | ||
| 6 | Paano Na Kaya* | $386,018 | ₱17,850,244 | ||
| 7 | ' | $669,572 | ₱31,034,662 | ||
| 8 | Percy Jackson & the Olympians: The Lightning Thief | $528,815 | ₱23,896,198 | ||
| 9 | Miss You Like Crazy* | $1,503,324 | ₱67,563,139 | ||
| 10 | Alice in Wonderland | $1,039,374 | ₱46,803,011 | ||
| 11 | Alice in Wonderland | $743,584 | ₱33,959,481 | ||
| 12 | Alice in Wonderland | $409,797 | ₱18,658,057 | ||
| 13 | How to Train Your Dragon | $380,628 | ₱17,274,802 | How to Train Your Dragon reached the #1 spot in its second weekend of release. | |
| 14 | Clash of the Titans | $1,052,679 | ₱47,275,814 | ||
| 15 | Clash of the Titans | $1,424,923 | ₱63,665,560 | ||
| 16 | Clash of the Titans | $645,684 | ₱28,500,879 | ||
| 18 | Iron Man 2 | $2,353,617 | ₱104,391,387 | ||
| 19 | Iron Man 2 | $1,602,405 | ₱71,671,249 | ||
| 20 | Here Comes the Bride* | $931,962 | ₱42,059,445 | ||
| 21 | Shrek Forever After | $1,274,851 | ₱59,382,560 | ||
| 22 | ' | $1,360,993 | ₱63,024,319 | ||
| 23 | Prince of Persia: Sands of Time | $840,662 | ₱39,087,588 | ||
| 24 | The Karate Kid | $952,208 | ₱44,182,451 | ||
| 25 | Toy Story 3 | $1,197,260 | ₱54,755,489 | ||
| 26 | Toy Story 3 | $978,483 | ₱45,091,432 | ||
| 27 | ' | $3,820,998 | ₱173,021,285 | The Twilight Saga: Eclipse had the highest weekend debut of 2010. | |
| 28 | The Twilight Saga: Eclipse | $1,135,972 | ₱52,342,863 | ||
| 29 | The Sorcerer's Apprentice | $847,816 | ₱38,519,587 | ||
| 30 | The Last Airbender | $1,229,252 | ₱56,121,623 | ||
| 31 | Salt | $1,283,189 | ₱58,295,276 | ||
| 32 | Salt | $679,008 | ₱30,330,608 | ||
| 33 | The Expendables | $490,066 | ₱22,160,785 | ||
| 34 | In Your Eyes* | $743,930 | ₱33,502,888 | ||
| 35 | In Your Eyes* | $276,578 | ₱12,420,841 | ||
| 36 | Despicable Me | $849,477 | ₱37,636,163 | ||
| 37 | Despicable Me | $701,993 | ₱30,895,414 | ||
| 38 | ' | $502,472 | ₱21,763,871 | Resident Evil: Afterlife reached the #1 spot in its second weekend of release. | |
| 39 | ' | $21,186,198 | ₱47,974,329 | ||
| 40 | Legend of the Guardians: The Owls of Ga'Hoole | $423,515 | ₱18,477,959 | ||
| 41 | Eat Pray Love | $249,844 | ₱10,710,787 | Eat Pray Love had the lowest weekend debut of 2010. | |
| 42 | Petrang Kabayo* | $1,231,752 | ₱53,240,879 | ||
| 43 | Petrang Kabayo* | $476,734 | ₱20,532,933 | ||
| 44 | Till My Heartaches End* | $770,985 | ₱33,022,367 | ||
| 45 | Megamind | $499,570 | ₱21,243,015 | ||
| 46 | Megamind | $388,522 | ₱16,964,813 | ||
| 47 | Harry Potter and the Deathly Hallows | $2,381,547 | ₱103,883,080 | ||
| 48 | Harry Potter and the Deathly Hallows | $1,063,843 | ₱46,914,944 | ||
| 51 | ' | $526,283 | ₱23,209,607 | ||
| 52 | $389,344 | ₱17,146,710 | Tron: Legacy reached the #1 spot in its second weekend of release. |
*Local Film