List of AM cannabinoids
is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. Some of those are:
Name | Class | Ki / nM at CB1 | Ki / nM at CB2 | Selectivity | CLogP | Structure |
AM-087 | Dibenzopyran | 0.43 | 6.47 | |||
AM-251 | Pyrazole derivative | 7.5 | 7.08 | |||
AM-279 | ||||||
AM-281 | ||||||
AM-356 | 17.9 | 868 | 5.55 | |||
AM-374 | ||||||
AM-381 | ||||||
AM-404 | 7.02 | |||||
AM-411 | 6.80 | 52.0 | ||||
AM-630 | 32.1 | CB2 | 4.19 | |||
AM-661 | ||||||
AM-678 | 9.00 ± 5.00 | 2.94 ± 2.65 | 5.68 | |||
AM-679 | 13.5 | 49.5 | 6.04 | |||
AM-694 | 0.08 | 1.44 | CB1 | 5.54 | ||
AM-735 | 8.9 | 7.4 | ||||
AM-855 | 22.3 | 58.6 | 7.1 | |||
AM-881 | 5.3 | 95 | ||||
AM-883 | 9.9 | 226 | ||||
AM-905 | 1.2 | 5.3 | 4.98 | |||
AM-906 | 0.8 | 9.5 | 4.98 | |||
AM-919 | 2.2 | 3.4 | 6.21 | |||
AM-926 | 2.2 | 4.3 | ||||
AM-938 | 1.2 | 0.3 | 5.92 | |||
AM-1116 | 7.4 | |||||
AM-1172 | ||||||
AM-1220 | 3.88 | 73.4 | 4.73 | |||
AM-1221 | 52.3 | 0.28 | CB2 | |||
AM-1235 | 1.5 | 20.4 | CB1 | |||
AM-1241 | 3.4 | CB2 | ||||
AM-1248 | ||||||
AM-1710 | Cannabilactone | CB2 | ||||
AM-1714 | Cannabilactone | CB2 | 6.17 | |||
AM-1902 | ||||||
AM-2201 | 1.0 | 2.6 | 5.18 | |||
AM-2212 | 1.4 | 18.9 | ||||
AM-2213 | 3.0 | 30 | CB1 | |||
AM-2232 | 0.28 | 1.48 | 4.75 | |||
AM-2233 | 1.8 | 2.2 | 5.09 | |||
AM-2389 | 0.16 | CB1 | 6 | |||
AM-3102 | 33000 | 26000 | ||||
AM-4030 | 0.7 | 8.6 | CB1 | 6.17 | ||
AM-4054 | 2.2 | CB1 | ||||
AM-4056 | 0.041 | 6.51 | ||||
AM-4113 | ||||||
AM-6545 | 4.06 |
- AM-087 — an analgesic CB1 agonist derived from Δ8THC substituted with a side chain on the 3-position, it has a Ki of 0.43nM making it roughly 100x as potent as THC.
- AM-251 — an inverse agonist at the CB1 cannabinoid receptor that is structurally related to SR141716A, but has a higher binding affinity with a Ki value of 7.5nM.
- AM-279 — a Schedule I substance in Alabama.
- AM-281 — N--1--5--4-methyl-1H-pyrazole-3-carboxamide
- AM-356 — a synthetically created stable chiral analog of anandamide, it acts on the cannabinoid receptors with a Ki of 17.9nM at CB1 and 868nM at CB2.
- AM-374 — palmitylsulfonyl fluoride
- AM-381 — stearylsulfonyl fluoride
- AM-404 — an active metabolite of paracetamol and a likely inhibitor of fatty acid amide hydrolase
- AM-411 — an adamantyl-substituted derivative of Δ8THC, it is a potent and fairly selective CB1 full agonist with a Ki of 6.80nM. It is also a moderately potent CB2 agonist with a Ki of 52.0nM.
- AM-630 — a potent and selective inverse agonist for the cannabinoid receptor CB2, with a Ki of 32.1nM at CB2 and 165x selectivity over CB1, at which it acts as a weak partial agonist.
- AM-661 — 1-methyl-2-methyl-3-benzoylindole
- AM-678 — another name for JWH-018, it is a full agonist at both cannabinoid receptors with some selectivity for CB2.
- AM-679 — an iodobenzoylindole which acts as a moderately potent agonist for the cannabinoid receptors, with a Ki of 13.5nM at CB1 and 49.5nM at CB2.
- AM-694 — an iodobenzoylindole which acts as a potent and selective agonist for the CB1 cannabinoid receptor, with a Ki of 0.08nM at CB1 and 18x selectivity over the related CB2 receptor.
- AM-735 — 3-bornyl-Δ8-THC, a mixed CB1 / CB2 agonist with Ki of 8.9nM at CB1 and 7.4nM at CB2.
- AM-855 — an analgesic derivative of Δ8tetrahydrocannabinol, it is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.
- AM-881 — a chlorine-substituted stereoisomer of anandamide whose Ki = 5.3nM at CB1 and 95nM at CB2.
- AM-883 — an allyl-substituted stereoisomer of anandamide whose Ki = 9.9nM at CB1 and 226nM at CB2.
- AM-905 — a potent and reasonably selective agonist for the CB1 cannabinoid receptor, with a Ki of 1.2nM at CB1 and 5.3nM at CB2.
- AM-906 — a potent and dodecally selective agonist for the CB1 cannabinoid receptor, with a Ki of 0.8nM at CB1 and 9.5nM at CB2.
- AM-919 — a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 2.2nM at CB1 and 3.4nM at CB2. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
- AM-926 — a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 2.2nM at CB1 and 4.3nM at CB2. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
- AM-938 — a potent agonist at both CB1 and CB2 with quadruple selectivity for CB2, with a Ki of 1.2nM at CB1 and 0.3nM at CB2. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
- AM-1116 — a dimethylated stereoisomer of anandamide whose Ki = 7.4nM at CB1.
- AM-1172 — an endocannabinoid analog specifically designed to be a potent and selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis.
- AM-1220 — a potent and selective analgesic CB1 agonist with a Ki of 3.88nM at CB1 and 73.4nM at CB2, giving it 19x selectivity for CB1. enantiomer has around 1000x higher affinity for CB1 than enantiomer.
- AM-1221 — a potent and selective CB2 agonist with a Ki of 0.28nM at CB2 and 52.3nM at CB1, giving it a selectivity of almost 187x.
- AM-1235 — a moderately CB1 selective agonist, with a Ki of 1.5nM at CB1 and 20.4nM at CB2, giving it a selectivity of around 13x.
- AM-1241 — a potent and selective analgesic CB2 agonist with a Ki of 3.4nM at CB2 and 80x selectivity over CB1.
- AM-1248 — a moderately potent agonist with some selectivity for CB1, containing an unusual 3- substitution on the indole ring.
- AM-1710 — a CB2 selective cannabilactone with 54x selectivity over CB1. Acts as a dual CB2 agonist / CB1 antagonist.
- AM-1714 — a CB2 selective cannabilactone with 490x selectivity over CB1.
- AM-1902 — a nonclassical cannabinoid
- AM-2201 — a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 1.0nM at CB1 and 2.6nM at CB2.
- AM-2212 — a potent agonist at both CB1 and CB2 with dodecal selectivity for CB1, with a Ki of 1.4nM at CB1 and 18.9nM at CB2.
- AM-2213 — a potent agonist at both CB1 and CB2 with 10x selectivity for CB1, with a Ki of 3.0M at CB1 and 30nM at CB2.
- AM-2232 — a potent agonist at both CB1 and CB2, with a Ki of 0.28nM at CB1 and 1.48nM at CB2.
- AM-2233 — enantiomer is potent and selective CB1 agonist used in 131I radiolabelled form to map distribution of CB1 receptors in brain.
- AM-2389 — classical cannabinoid derivative with 26x selectivity for CB1.
- AM-3102 — an analog of oleoylethanolamide, the endogenous agonist for proliferator-activated receptor α. It also acts as a weak cannabinoid agonist with Ki values of 33μM at CB1 and 26μM at CB2.
- AM-4030 — a potent agonist at both CB1 and CB2, it is dodecally selective for CB1, with a Ki of 0.7nM at CB1 and 8.6nM at CB2. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
- AM-4054 — a potent but slow-onset agonist with CB1 affinity of 2.2nM and a 40x selectivity for CB1 over CB2.
- AM-4056 — Another name for HU-243, it is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.041 nM at the CB1 receptor.
- AM-4113 — a CB1 selective neutral antagonist.
- AM-6545 — a peripherally selective silent antagonist of CB1 receptors.