List of Phineas and Ferb guest stars
This is a list of guest stars who have appeared on the Disney animated musical comedy television series, Phineas and Ferb. Per Academy of Television Arts & Sciences guidelines, individuals appearing in more than half of a given season's episodes will be considered "recurring" and will not be included on the list.
Season 1">Phineas and Ferb (season 1)">Season 1
| Name | Role | Episode |
| Keone Young | Queen Wahini crowner | "Lawn Gnome Beach Party of Terror" Episode 2 |
| Jeff Bennett | Ben Baxter | "Flop Starz" Episode 3 |
| Brian Phelps | Announcer Rick | "The Fast and the Phineas" Episode 4 |
| Mark Thompson | Announcer Dave | "The Fast and the Phineas" Episode 4 |
| Michael Buffer | Announcer | "Raging Bully" Episode 6 |
| Evander Holyfield | Himself | "Raging Bully" Episode 6 |
| French Stewart | Gaston Le Mode | "Run Away Runaway" Episode 9 |
| Lucy Davis | Crash | "Ready for the Bettys" Episode 14 |
| Allison Janney | Charlene Doofenshmirtz | "I Scream, You Scream" Episode 15 |
| Ming-Na Wen | Dr. Hirano | "I Scream, You Scream" Episode 15 |
| J. K. Simmons | J.B. | "Toy to the World" Episode 16 |
| April Winchell | Bridgette Oshinomi | "Toy to the World" Episode 16 |
| Barry Bostwick | Grandpa Clyde | "Get That Bigfoot Outta My Face!" Episode 17 |
| Sandra Oh | Doofenshmirtz's girlfriend | "Get That Bigfoot Outta My Face!" Episode 17 |
| Billy Ray Cyrus | Buck Buckerson | "It's a Mud, Mud, Mud, Mud World" Episode 18 |
| Allison Janney | Charlene Doofenshmirtz | "It's a Mud, Mud, Mud, Mud World" Episode 18 |
| Carlos Alazraqui | Dr. Feelbetter | "It's About Time!" Episode 21 |
| Carlos Alazraqui | Bobbi Fabulous | "Dude, We're Getting the Band Back Together" Episode 22 |
| Susanne Blakeslee | The Love-a-gram | "Dude, We're Getting the Band Back Together" Episode 22 |
| John DiMaggio | Johnny "Love on the Run" guy | "Dude, We're Getting the Band Back Together" Episode 22 |
| Jaret Reddick | Danny | "Dude, We're Getting the Band Back Together" Episode 22 |
| Steve Zahn | Sherman "Swampy" | "Dude, We're Getting the Band Back Together" Episode 22 |
| Jeff Bennett | Talking Zebra | "The Ballad of Badbeard" Episode 24 |
| Barry Bostwick | Grandpa Clyde | "The Ballad of Badbeard" Episode 24 |
| Vicki Lewis | Lulu | "Leave the Busting to Us" Episode 26 |
| Gwendoline Yeo | Fifi | "Leave the Busting to Us" Episode 26 |
| Barry Bostwick | Grandpa Clyde | "Crack That Whip" Episode 27 |
| Vicki Lawrence | Hildegard | "Crack That Whip" Episode 27 |
| Diedrich Bader | Vance Ward | "The Best Lazy Day Ever" Episode 28 |
| John DiMaggio | Conk | "Boyfriend from 27,000 B.C." Episode 29 |
| Jane Carr | Grandma Winnie | "A Hard Day's Knight" Episode 31 |
| Tim Curry | Stubbings Dr. Lloyd Wexler | "A Hard Day's Knight" Episode 31 |
| Malcolm McDowell | Grandpa Reg | "A Hard Day's Knight" Episode 31 |
| Dominic Wood | Charles | "A Hard Day's Knight" Episode 31 |
| Jess Harnell | Shady Joe | "Bowl-R-Ama Drama" Episode 33 |
| April Winchell | Shopkeeper | "Got Game?" Episode 34 |
| Phil LaMarr | Street Performer #1 | "Comet Kermillian" Episode 35 |
| Charlie Schlatter | Street Performer #2 | "Comet Kermillian" Episode 35 |
| Rob Paulsen | Scottsman | "Put That Putter Away" Episode 36 |
| Rob Paulsen | Mad Scientist | "Does This Duckbill Make Me Look Fat?" Episode 37 |
| Ming-Na Wen | Dr. Hirano | "Does This Duckbill Make Me Look Fat?" Episode 37 |
| Jane Carr | Grandma Winnie | "The Flying Fishmonger" Episode 38 |
| Malcolm McDowell | Grandpa Reg | "The Flying Fishmonger" Episode 38 |
| Jane Carr | Grandma Winnie | "The Monster of Phineas-n-Ferbenstein" Episode 40 |
| Greg Ellis | Jameson | "The Monster of Phineas-n-Ferbenstein" Episode 40 |
| Malcolm McDowell | Grandpa Reg | "The Monster of Phineas-n-Ferbenstein" Episode 40 |
| Jennifer Grey | Dr. Gevaarlijk | "Oil on Candace" Episode 41 |
| Joel Grey | Beppo | "Oil on Candace" Episode 41 |
| John DiMaggio | Pinhead Pierre | "Out of Toon" Episode 42 |
| Allison Janney | Charlene Doofenshmirtz | "Hail Doofania!" Episode 43 |
| Keith Ferguson | Ronaldo Gretchen's countdown voice | "Out to Launch" Episode 44 |
| Brian George | Bouncer | "Out to Launch" Episode 44 |
| Lara Jill Miller | Sylvia | "Out to Launch" Episode 44 |
| Jeff Bennett | Talking Zebra | "Phineas and Ferb Get Busted" Episode 45 |
| Clancy Brown | Drill Sergeant | "Phineas and Ferb Get Busted" Episode 45 |
| Geraldo Rivera | Morty Williams | "Phineas and Ferb Get Busted" Episode 45 |
| Brenda Song | Wendy | "Unfair Science Fair" Episode 46 |
| Brian Stepanek | Mr. McGillicuddy Mr. Slushy Burger manager | "Unfair Science Fair" Episode 46 |
| Kari Wahlgren | Baking soda volcano girl | "Unfair Science Fair" Episode 46 |
| Tom Kenny | Scientist | "Unfair Science Fair Redux " Episode 47 |
| Brian Stepanek | Mr. Slushy Burger manager | "Unfair Science Fair Redux " Episode 47 |
Season 2">Phineas and Ferb (season 2)">Season 2
| Name | Role | Episode |
| John Larroquette | Bob Webber | "The Lake Nose Monster" Episode 1 |
| Tara Strong | Little girl | "The Lake Nose Monster" Episode 1 |
| Tom Kenny | The Squirrel | "Interview with a Platypus" Episode 2 |
| Tara Strong | The Bird | "Interview with a Platypus" Episode 2 |
| Keith Ferguson | Announcer from "Flawless Girl" | "Attack of the 50 Foot Sister" Episode 4 |
| Kevin Michael Richardson | P.P. Otter | "Attack of the 50 Foot Sister" Episode 4 |
| April Winchell | Blanca Dishon | "Attack of the 50 Foot Sister" Episode 4 |
| Keith Ferguson | Herman | "Backyard Aquarium" Episode 5 |
| April Winchell | Bridgette Oshinomi | "Backyard Aquarium" Episode 5 |
| Clancy Brown | The Gelatin Monster | "Day of the Living Gelatin" Episode 6 |
| Jane Leeves | Admiral Acronym | "Day of the Living Gelatin" Episode 6 |
| Jane Carr | Grandma Winnie | "Elementary, My Dear Stacy" Episode 7 |
| Jane Leeves | Inspector Initials | "Elementary, My Dear Stacy" Episode 7 |
| Damian Lewis | Agent Double O-O | "Elementary, My Dear Stacy" Episode 7 |
| Malcolm McDowell | Grandpa Reg | "Elementary, My Dear Stacy" Episode 7 |
| Sheena Easton | Doofenshmirtz's date | "Chez Platypus" Episode 9 |
| Corey Burton | Documentary narrator | "Perry Lays an Egg" Episode 10 |
| Kari Wahlgren | Elizabeth | "Perry Lays an Egg" Episode 10 |
| Don LaFontaine | Movie voice over announcer | "The Chronicles of Meap" Episode 12 |
| Lorenzo Lamas | Meap | "The Chronicles of Meap" Episode 12 |
| David Mitchell | Mitch | "The Chronicles of Meap" Episode 12 |
| Danny Cooksey | Thaddeus | "Thaddeus and Thor" Episode 13 |
| Allison Janney | Charlene Doofenshmirtz | "Thaddeus and Thor" Episode 13 |
| Cloris Leachman | Dr. Doofenshmirtz's mother | "Thaddeus and Thor" Episode 13 |
| Jaret Reddick | Danny | "Thaddeus and Thor" Episode 13 |
| Aliki Theofilopoulos | Mandy | "Thaddeus and Thor" Episode 13 |
| Shae Brewster | Nicolette | "De Plane! De Plane!" Episode 14 |
| Cloris Leachman | Dr. Doofenshmirtz's mother | "De Plane! De Plane!" Episode 14 |
| Corbin Bleu | Coltrane | "Let's Take a Quiz" Episode 15 |
| Clancy Brown | The Regurgitator | "Oh, There You Are, Perry" Episode 17 |
| Jennifer Stone | Woman with a pet beaver | "Oh, There You Are, Perry" Episode 17 |
| Tiya Sircar | Mishti | "That Sinking Feeling" Episode 20 |
| Meera Syal | Baljeet's mother | "That Sinking Feeling" Episode 20 |
| Corbin Bleu | Coltrane | "The Baljeatles" Episode 21 |
| Jennifer Stone | The Mailwoman | "No More Bunny Business" Episode 23 |
| April Winchell | Forewoman | "Spa Day" Episode 24 |
| Moises Arias | Fred | "Phineas and Ferb's Quantum Boogaloo" Episode 25 |
| Bowling for Soup | Themselves | "Phineas and Ferb's Quantum Boogaloo" Episode 25 |
| Jennifer Grey | Librarian | "Phineas and Ferb's Quantum Boogaloo" Episode 25 |
| Noah Munck | Xavier | "Phineas and Ferb's Quantum Boogaloo" Episode 25 |
| Jennifer Stone | Amanda | "Phineas and Ferb's Quantum Boogaloo" Episode 25 |
| Jane Leeves | Admiral Acronym | "Isabella and the Temple of Sap" Episode 28 |
| Judd Nelson | The Guru | "Isabella and the Temple of Sap" Episode 28 |
| Amanda Plummer | Professor Poofenplotz | "Isabella and the Temple of Sap" Episode 28 |
| Cloris Leachman | Eliza M. Feyersied | "Fireside Girl Jamboree" Episode 30 |
| Allison Janney | Charlene Doofenshmirtz | "Finding Mary McGuffin" Episode 32 |
| Candi Milo | Sally | "Finding Mary McGuffin" Episode 32 |
| Jane Carr | Grandma Winnie | "Picture This" Episode 33 |
| Malcolm McDowell | Grandpa Reg | "Picture This" Episode 33 |
| Jane Leeves | Nikki Stars | "Nerdy Dancin'" Episode 34 |
| Big Bad Voodoo Daddy | Themselves | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Corey Burton | WJOP worker | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Jane Carr | Grandma Winnie | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Bill Fagerbakke | Frosty the Snowman | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Mathew Horne | Blay'n | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Bruce Mackinnon | Clewn't | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Malcolm McDowell | Grandpa Reg | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Adam West | Santa Claus | "Phineas and Ferb Christmas Vacation" Episode 37 |
| Ariel Winter | Wendy Stinglehopper | "Phineas and Ferb Christmas Vacation" Episode 37 |
| John Schneider | Wilbur Wilkins | "Just Passing Through" Episode 38 |
| Tom Wopat | Orville Wilkins | "Just Passing Through" Episode 38 |
| Megan Hilty | Aunt Tiana | "Candace's Big Day" Episode 39 |
| John Larroquette | Uncle Bob | "Candace's Big Day" Episode 39 |
| Jaret Reddick | Danny | "Hip Hip Parade" Episode 43 |
| Adam Wylie | Buford's new nerd | "Hip Hip Parade" Episode 43 |
| Pamela Adlon | Buford's mother | "Not Phineas and Ferb" Episode 46 |
| Diedrich Bader | Albert | "Not Phineas and Ferb" Episode 46 |
| Jennifer Grey | Baljeet's mother | "Not Phineas and Ferb" Episode 46 |
| Amber Valletta | Mrs. DuBois | "Not Phineas and Ferb" Episode 46 |
| Ming-Na Wen | Dr. Hirano | "Robot Rodeo" Episode 49 |
| Pamela Adlon | Melanie | "The Beak" Episode 50 |
| Ben Stiller | Khaka Peü Peü | "The Beak" Episode 50 |
| Christine Taylor | Mrs. Khaka Peü Peü | "The Beak" Episode 50 |
| Pamela Adlon | Melanie | "She's the Mayor" Episode 51 |
| Laird Hamilton | Himself | "Phineas and Ferb Hawaiian Vacation" Episode 53 |
| Phill Lewis | Hotel manager | "Phineas and Ferb Hawaiian Vacation" Episode 53 |
| Allie MacKay | Yoga instructor | "Phineas and Ferb Hawaiian Vacation" Episode 53 |
| Clay Aiken | Himself | "" Episode 54 |
| Brian George | Uncle Sabu | "" Episode 54 |
| Chaka Khan | Herself | "" Episode 54 |
| Lauren Tom | Bāchan Hirano | "" Episode 54 |
| Diedrich Bader | Albert | "Nerds of a Feather" Episode 55 |
| Jeff Bennett | The Talking Zebra | "Nerds of a Feather" Episode 55 |
| Seth MacFarlane | Jeff McGarland | "Nerds of a Feather" Episode 55 |
| Kevin Smith | Clive Addison | "Nerds of a Feather" Episode 55 |
| Kari Wahlgren | "Ducky Momo" vendor | "Nerds of a Feather" Episode 55 |
| Diedrich Bader | Albert | "The Doof Side of the Moon" Episode 60 |
| Allison Janney | Charlene Doofenshmirtz | "Brain Drain" Episode 62 |
| Logan Miller | Johnny | "Brain Drain" Episode 62 |
| Corbin Bleu | Coltrane | "" Episode 63 |
| Lorenzo Lamas | Meap | "" Episode 63 |
| Kenny Ortega | Himself | "" Episode 63 |
| Sophia Bush | Sara | "Candace Gets Busted" Episode 65 |
Season 3">Phineas and Ferb (season 3)">Season 3
| Name | Role | Episode |
| Andrés Cantor | Spanish announcer | "The Great Indoors" Episode 1 |
| Erik Estrada | Juan | "The Great Indoors" Episode 1 |
| Jane Lynch | Mrs. Johnson | "Canderemy" Episode 2 |
| Tina Fey | Annabelle Johnson | "Run, Candace, Run" Episode 3 |
| Vicki Lawrence | Hildegard Johnson | "Run, Candace, Run" Episode 3 |
| Jane Lynch | Mrs. Johnson | "Run, Candace, Run" Episode 3 |
| Todd Stashwick | Mr. Johnson | "Run, Candace, Run" Episode 3 |
| Barry Bostwick | Grandpa Clyde | "Last Train to Bustville" Episode 4 |
| Joan Cusack | Glenda Wilkins | "Last Train to Bustville" Episode 4 |
| John Schneider | Wilbur Wilkins | "Last Train to Bustville" Episode 4 |
| Tom Wopat | Orville Wilkins | "Last Train to Bustville" Episode 4 |
| Pamela Adlon | Buford's mother | "Phineas' Birthday Clip-O-Rama!" Episode 5 |
| April Winchell | Construction lady | "Phineas' Birthday Clip-O-Rama!" Episode 5 |
| Nick Frost | Captain Squint | "The Belly of the Beast" Episode 6 |
| Corey Burton | The Super-Computer | "Ask a Foolish Question" Episode 8 |
| Lisa Ling | Tykera Kwok | "Misperceived Monotreme" Episode 9 |
| Joel McHale | Norm head prototype | "Candace Disconnected" Episode 10 |
| John DiMaggio | Pinhead Pierre | "Magic Carpet Ride" Episode 11 |
| Jane Lynch | Mrs. Johnson | "Bad Hair Day" Episode 12 |
| Davy Jones | Nigel | "Meatloaf Surprise" Episode 13 |
| Peter Noone | Adrian | "Meatloaf Surprise" Episode 13 |
| Jamie Oliver | Himself | "Meatloaf Surprise" Episode 13 |
| Greg LeMond | Himself | "Tour de Ferb" Episode 18 |
| Logan Miller | Johnny | "Skiddley Whiffers" Episode 19 |
| Darren Bent | Sniffleton Nostrils player #2 | "My Fair Goalie" Episode 20 |
| Jane Horrocks | Eliza | "My Fair Goalie" Episode 20 |
| Phill Jupitus | Adrian Fletcher | "My Fair Goalie" Episode 20 |
| Gary Lineker | Sniffleton Nostrils player #1 | "My Fair Goalie" Episode 20 |
| Helen McCrory | Lucy Fletcher | "My Fair Goalie" Episode 20 |
| Daniel Roche | Beckham with half-moon glasses | "My Fair Goalie" Episode 20 |
| Tom Bergeron | "L.O.V.E.M.U.F.F.I.N." host | "Bullseye!" Episode 21 |
| Michael Douglas | Waylon | "That's the Spirit!" Episode 22 |
| Tom Kenny | Jack-O-Lantern | "That's the Spirit!" Episode 22 |
| April Winchell | Mona Bridgette Oshinomi | "That's the Spirit!" Episode 22 |
| Michael J. Fox | Michael | "The Curse of Candace" Episode 23 |
| Danny Jacob | Narrator | "The Curse of Candace" Episode 23 |
| Stephen Moyer | Jared | "The Curse of Candace" Episode 23 |
| Anna Paquin | Kristen | "The Curse of Candace" Episode 23 |
| Carol Kane | Nana Shapiro | "Lotsa Latkes" Episode 25 |
| Kelly Clarkson | Herself | "A Phineas and Ferb Family Christmas" Episode 27 |
| Carlos Alazraqui | Bobbi Fabulous | "Tri-Stone Area" Episode 28 |
| John DiMaggio | Conk | "Tri-Stone Area" Episode 28 |
| Robert F. Hughes | Old Phineas | "Doof Dynasty" Episode 29 |
| Allison Janney | The Lady of the Lake | "Excaliferb!" Episode 30 |
| Amanda Plummer | Keeper of the Bridge of Comprehension | "Excaliferb!" Episode 30 |
| Eric Bauza | Li'l Saul | "The Remains of the Platypus" Episode 34 |
| Diedrich Bader | Tom Totally | "Perry the Actorpus" Episode 36 |
| Richard Kind | Totally Tools executive | "Perry the Actorpus" Episode 36 |
| George Takei | Positive reinforcement machine | "Perry the Actorpus" Episode 36 |
| Jane Lynch | Mrs. Johnson Liar #1 | "Let's Bounce" Episode 37 |
| Todd Stashwick | Mr. Johnson | "Let's Bounce" Episode 37 |
| Jennifer Grey | Svetka | "The Doonkelberry Imperative" Episode 40 |
| John Hodgman | Zengle | "The Doonkelberry Imperative" Episode 40 |
| Jeff Foxworthy | Southern Meap | "Meapless in Seattle" Episode 41 |
| Lorenzo Lamas | Meap | "Meapless in Seattle" Episode 41 |
| David Mitchell | Mitch | "Meapless in Seattle" Episode 41 |
| Carlos Alazraqui | Bobbi Fabulous | "Delivery of Destiny" Episode 42 |
| Simon Pegg | Paul the delivery guy | "Delivery of Destiny" Episode 42 |
| Brian Phelps | Paul's dad | "Delivery of Destiny" Episode 42 |
| Jaret Reddick | Danny | "Delivery of Destiny" Episode 42 |
| Christian Slater | Paul the delivery guy | "Delivery of Destiny" Episode 42 |
| Mark Thompson | Radio DJ | "Delivery of Destiny" Episode 42 |
| Steve Zahn | Sherman "Swampy" | "Delivery of Destiny" Episode 42 |
| Barry Bostwick | Grandpa Clyde | "Buford Confidential" Episode 43 |
| Matthew Lillard | "additional voices" | "Buford Confidential" Episode 43 |
| Danica McKellar | Josette Collette | "Buford Confidential" Episode 43 |
| Jorge Garcia | Rodrigo | "Minor Monogram" Episode 47 |
| Seth Green | Monty Monogram | "Minor Monogram" Episode 47 |
| Ray Liotta | Himself | "What A Croc!" Episode 48 |
| Guy Fieri | Pizza guy | "Sci-Fi Pie Fly" Episode 50 |
| Seth Green | Flomby | "Sci-Fi Pie Fly" Episode 50 |
| Rob Paulsen | Romantic man from the TV | "Sci-Fi Pie Fly" Episode 50 |
| Seth Green | Monty Monogram | "Sipping with the Enemy" Episode 51 |
| Jennifer Hale | Female customer | "Sipping with the Enemy" Episode 51 |
| Mikey Kelley | Cashier Male customer #4 | "Sipping with the Enemy" Episode 51 |
| Tim Curry | Worthington DuBois | "Tri-State Treasure: Boot of Secrets" Episode 52 |
| Mikey Kelley | Announcer | "Tri-State Treasure: Boot of Secrets" Episode 52 |
| Rob Morrow | Flea market salesman | "Tri-State Treasure: Boot of Secrets" Episode 52 |
| Jonathan Ross | Flea market salesman | "Tri-State Treasure: Boot of Secrets" Episode 52 |
| Alan Tudyk | Salesman #2 | "Tri-State Treasure: Boot of Secrets" Episode 52 |
| Grey DeLisle | Judge | "Norm Unleashed" Episode 54 |
| Lorraine Kelly | Judge | "Norm Unleashed" Episode 54 |
| Barry Bostwick | Grandpa Clyde | "Where's Perry?" Episodes 55/56 |
| Edi Gathegi | Ignatius Ukareamü | "Where's Perry?" Episodes 55/56 |
| Lenny Henry | Ignatius Ukareamü | "Where's Perry?" Episodes 55/56 |
| Harold Perrineau | Maître d' | "Where's Perry?" Episodes 55/56 |
| Vanessa L. Williams | Flight attendant | "Where's Perry?" Episodes 55/56 |
| Lorenzo Lamas | Meap | "Ferb TV" Episode 57 |
| Grey DeLisle | Lady on the bus | "Road to Danville" Episode 60 |
| Allison Janney | Charlene Doofenshmirtz | "This Is Your Backstory" Episode 61 |
| Cloris Leachman | Dr. Doofenshmirtz's mother | "This Is Your Backstory" Episode 61 |
Season 4">Phineas and Ferb (season 4)">Season 4
and Nick Frost reprise their roles as Shaun and Ed from the 2004 comedy horror film, Shaun of the Dead in the 44th episode of the final season.
| Name | Role | Episode |
| Luc Robitaille | Himself | "For Your Ice Only" Episode 1 |
| Martin Olson | Human head fly | "Fly on the Wall" Episode 3 |
| Jennifer Grey | Baljeet's mother | "My Sweet Ride" Episode 5 |
| Jane Lynch | Mrs. Johnson | "My Sweet Ride" Episode 5 |
| Pamela Adlon | Melanie | "Der Kinderlumper" Episode 6 |
| Cloris Leachman | Dr. Doofenshmirtz's mother | "Der Kinderlumper" Episode 6 |
| Samantha Bee | Lyla Loliberry | "Sidetracked" Episode 7 |
| Kevin McDonald | Prof. Bannister | "Sidetracked" Episode 7 |
| Deborra-Lee Furness | Liam's mum | "Primal Perry" Episode 8 |
| Jesse Spencer | Liam McCracken | "Primal Perry" Episode 8 |
| Carlos Alazraqui | Morg | "Mind Share" Episode 9 |
| Lorenzo Lamas | Meap | "Mind Share" Episode 9 |
| Jaime Pressly | Rosie | "Mind Share" Episode 9 |
| Parry Gripp | Himself | "Backyard Hodge Podge" Episode 10 |
| Allison Janney | Charlene Doofenshmirtz | "Bee Day" Episode 11 |
| Jennifer Hale | Carla | "Bee Story" Episode 12 |
| Jane Leeves | Admiral Acronym Queen Bee | "Bee Story" Episode 12 |
| Amanda Plummer | Prof. Poofenplotz | "Bee Story" Episode 12 |
| Wayne Brady | Don, the City Hall guide | "Where's Pinky?" Episode 14 |
| Maia Mitchell | Herself | "Phineas and Ferb's Musical Cliptastic Countdown Hosted by Kelly Osbourne" Episode 15 |
| Kelly Osbourne | Herself | "Phineas and Ferb's Musical Cliptastic Countdown Hosted by Kelly Osbourne" Episode 15 |
| Jennifer Wong | Chloe | "Love at First Byte" Episode 20 |
| Pamela Adlon | Melanie | "One Good Turn" Episode 21 |
| Billy Gardell | Mayor Chickenen | "One Good Turn" Episode 21 |
| Ming-Na Wen | Dr. Hirano | "One Good Turn" Episode 21 |
| Charlie Adler | MODOK | "" Episode 22 |
| Drake Bell | Spider-Man | "" Episode 22 |
| Stan Lee | New York City hot dog vendor Narrator | "" Episode 22 |
| Allie MacKay | Little old lady | "" Episode 22 |
| Chi McBride | Nick Fury | "" Episode 22 |
| Liam O'Brien | Red Skull | "" Episode 22 |
| Adrian Pasdar | Iron Man | "" Episode 22 |
| Peter Stormare | Whiplash | "" Episode 22 |
| Fred Tatasciore | Hulk | "" Episode 22 |
| Danny Trejo | Venom | "" Episode 22 |
| Travis Willingham | Thor | "" Episode 22 |
| Seth Green | Monty Monogram | "Thanks But No Thanks" Episode 23 |
| Goldie Hawn | Peggy McGee | "Thanks But No Thanks" Episode 23 |
| Gordon Ramsay | Chef | "Thanks But No Thanks" Episode 23 |
| Diedrich Bader | Albert | "Troy Story" Episode 24 |
| Leah Remini | Doreen | "Troy Story" Episode 24 |
| Seth Green | Monty Monogram | "Druselsteinoween" Episode 25 |
| Oliver Chris | Mr. Macabre | "Terrifying Tri-State Trilogy of Terror" Episode 26 |
| Jay Harris | Bank officer | "Terrifying Tri-State Trilogy of Terror" Episode 26 |
| Alex Hirsch | Officer Concord | "Terrifying Tri-State Trilogy of Terror" Episode 26 |
| David Koechner | Rusty Bridges | "Terrifying Tri-State Trilogy of Terror" Episode 26 |
| Todd Stashwick | Mr. Johnson | "Face Your Fear" Episode 27 |
| Carlos Alazraqui | Bobbi Fabulous | "Cheers for Fears" Episode 28 |
| Jaret Reddick | Danny | "Cheers for Fears" Episode 28 |
| Paul Alborough | Professor Elemental | "Steampunx" Episode 29 |
| Samantha Bee | Lyla Loliberry Food truck girl | "Just Our Luck" Episode 30 |
| Danny Jacob | Himself | "Just Our Luck" Episode 30 |
| Jason Sklar | Mark | "Just Our Luck" Episode 30 |
| Randy Sklar | Markus | "Just Our Luck" Episode 30 |
| Jeremy Clarkson | Adrian | "Live and Let Drive" Episode 32 |
| Patrick Dempsey | Paolo Vanderbeek | "Live and Let Drive" Episode 32 |
| Richard Hammond | Nigel | "Live and Let Drive" Episode 32 |
| James May | Ian | "Live and Let Drive" Episode 32 |
| Jay Leno | Col. Contraction | "Phineas and Ferb Save Summer" Episode 33 |
| Kevin Michael Richardson | President Barack Obama | "Phineas and Ferb Save Summer" Episode 33 |
| Wallace Shawn | Saul | "Phineas and Ferb Save Summer" Episode 33 |
| Dee Bradley Baker | Mr. Doofenshmirtz | "Father's Day" Episode 34 |
| Malcolm McDowell | Grandpa Reg | "Father's Day" Episode 34 |
| Elizabeth Banks | Grulinda | "Imperfect Storm" Episode 35 |
| Simon Pegg | Pierre | "Imperfect Storm" Episode 35 |
| Jon Stewart | Mr. Random | "The Klimpaloon Ultimatum" Episode 38 |
| Jamie Hyneman | Office stormtrooper | "" Episode 41 |
| Simon Pegg | Candace's commanding officer C-3PO | "" Episode 41 |
| Adam Savage | Office stormtrooper | "" Episode 41 |
| Jane Kaczmarek | Denise | "Lost in Danville" Episode 42 |
| Rob Morrow | Bernie | "Lost in Danville" Episode 42 |
| Terry O'Quinn | Prof. Mystery | "Lost in Danville" Episode 42 |
| Nick Frost | Ed | "Night of the Living Pharmacists" Episode 44 |
| Cloris Leachman | Eliza M. Feyersied | "Night of the Living Pharmacists" Episode 44 |
| Simon Pegg | Shaun | "Night of the Living Pharmacists" Episode 44 |
| George A. Romero | Don Adaded | "Night of the Living Pharmacists" Episode 44 |
| Bella Thorne | Brigitte | "Night of the Living Pharmacists" Episode 44 |
| Noah Wyle | Martin, the news vendor | "Night of the Living Pharmacists" Episode 44 |
| Allison Janney | Charlene Doofenshmirtz | "Tales from the Resistance: Back to the 2nd Dimension" Episode 45 |
| Gary Cole | Principal Lang | "Doof 101" Episode 46 |
| Josh Gad | Wendell | "Doof 101" Episode 46 |
| Jennifer Grey | Mrs. Pierpont | "Doof 101" Episode 46 |
| Danica McKellar | Becky | "Doof 101" Episode 46 |
| Logan Miller | Johnny | "Doof 101" Episode 46 |
| Stephen Root | Floyd | "Doof 101" Episode 46 |
| JK Simmons | Napoleon | "Doof 101" Episode 46 |
Film
The following appeared as guest stars in .| Name | Role |
| Carlos Alazraqui | Spanish announcer |
| Jaret Reddick | Danny |
| Doris Roberts | Mrs. Thompson |
| Slash | Himself |
| Steve Zahn | Sherman "Swampy" |