List of best-selling music downloads of the 2000s in the United Kingdom
Sales of music downloads in the United Kingdom have been monitored since 2004; during the 2000s, these sales were collated by the Official Charts Company and compiled weekly into the UK Official Download Chart, a record chart of the biggest-selling downloads in the UK.
In September 2009, The Daily Telegraph published a chart of what were the best-selling music downloads of the decade to that point. American singer Lady Gaga was number one with her 2009 single "Poker Face".
Several songs sold a significant amount in the final four months of the decade, after The Daily Telegraph list was published. These songs include "Bad Boys" by Alexandra Burke, "Fight for This Love" by Cheryl Cole, and "Killing in the Name" by Rage Against the Machine, which sold more than half a million copies in one week to become the 2009 Christmas number one.
Best-selling music downloads
| Artist | Song | Record label | Year | Chart peak | |
| 1 | Lady Gaga | "Poker Face" | Warner | 2009 | 1 |
| 2 | Kings of Leon | "Sex on Fire" | Sony | 2008 | 1 |
| 3 | Lady Gaga | "Just Dance" | Warner | 2009 | 1 |
| 4 | Kings of Leon | "Use Somebody" | Sony | 2008 | 2 |
| 5 | La Roux | "In for the Kill" | Warner | 2009 | 2 |
| 6 | "Run" | Sony | 2008 | 1 | |
| 7 | "Hallelujah" | Sony | 2008 | 1 | |
| 8 | "Bleeding Love" | Sony | 2007 | 1 | |
| 9 | Snow Patrol | "Chasing Cars" | Universal | 2006 | 2 |
| 10 | Nickelback | "Rockstar" | Warner | 2007 | 1 |
| 11 | "I Kissed a Girl" | EMI | 2008 | 1 | |
| 12 | Beyoncé | "If I Were a Boy" | Sony | 2008 | 1 |
| 13 | Rihanna featuring Jay-Z | "Umbrella" | Universal | 2007 | 1 |
| 14 | Take That | "Rule the World" | Universal | 2007 | 2 |
| 15 | featuring Nelly Furtado | "Broken Strings" | Universal | 2008 | 2 |
| 16 | "Boom Boom Pow" | Universal | 2009 | 1 | |
| 17 | Duffy | "Mercy" | Universal | 2008 | 1 |
| 18 | Gnarls Barkley | "Crazy" | Warner | 2006 | 1 |
| 19 | "Hot n Cold" | EMI | 2008 | 4 | |
| 20 | Dizzee Rascal featuring Calvin Harris and Chrome | "Dance wiv Me" | Dirtee Stank | 2008 | 1 |
| 21 | Tinchy Stryder featuring N-Dubz | "Number 1" | Universal | 2009 | 1 |
| 22 | "Human" | Universal | 2008 | 2 | |
| 23 | Pink | "So What" | Sony | 2008 | 1 |
| 24 | "" | EMI | 2009 | 1 | |
| 25 | Estelle featuring Kanye West | "American Boy" | Warner | 2008 | 1 |
| 26 | Flo Rida featuring T-Pain | "Low" | Warner | 2008 | 2 |
| 27 | "Black and Gold" | Universal | 2008 | 2 | |
| 28 | Timbaland presents OneRepublic | "Apologize" | Universal | 2007 | 1 |
| 29 | Girls Aloud | "" | Universal | 2008 | 1 |
| 30 | Mika | "Grace Kelly" | Universal | 2007 | 1 |
| 31 | "I Gotta Feeling" | Universal | 2009 | 1 | |
| 32 | featuring Amy Winehouse | "Valerie" | Sony | 2007 | 2 |
| 33 | Rihanna | "Disturbia" | Universal | 2008 | 2 |
| 34 | Coldplay | "Viva la Vida" | EMI | 2008 | 1 |
| 35 | Dizzee Rascal & Armand Van Helden | "Bonkers" | Dirtee Stank | 2009 | 1 |
| 36 | Flo Rida featuring Ke$ha | "Right Round" | Universal | 2009 | 1 |
| 37 | Madonna featuring Justin Timberlake | "4 Minutes" | Warner | 2008 | 1 |
| 38 | Sugababes | "About You Now" | Universal | 2007 | 1 |
| 39 | and The Pussycat Dolls featuring Nicole Scherzinger | "Jai Ho! " | Universal | 2009 | 3 |
| 40 | "I'm Not Alone" | Sony | 2009 | 1 |