List of corticosteroids
This is a list of corticosteroids or derivatives of cortisol. Most esters of these corticosteroids are not included in this list; for esters, see here instead.
The most common structural modifications in synthetic corticosteroids include 1-dehydrogenation, 6α-, 9α-, 16α-, and 16β-substitution, 16α,17α-acetonidation, and 17α- and 21-esterification.
Natural
- 11-Dehydrocorticosterone = 21-hydroxypregn-4-ene-3,11,20-trione
- 11-Deoxycorticosterone = 21-hydroxypregn-4-ene-3,20-dione
- 11-Deoxycortisol = 17α,21-dihydroxypregn-4-ene-3,20-dione
- 11-Ketoprogesterone = pregn-4-ene-3,11,20-trione
- 11β-Hydroxypregnenolone = 3β,11β-dihydroxypregn-5-en-20-one
- 11β-Hydroxyprogesterone = 11β-hydroxypregn-4-ene-3,20-dione
- 11β,17α,21-Trihydroxypregnenolone = 3β,11β,17α,21-tetrahydroxypregn-5-en-20-one
- 17α,21-Dihydroxypregnenolone = 3β,17α,21-trihydroxypregn-5-en-20-one
- 17α-Hydroxypregnenolone = 3β,17α-dihydroxypregn-5-en-20-one
- 17α-Hydroxyprogesterone = 17α-hydroxypregn-4-ene-3,11,20-trione
- 18-Hydroxy-11-deoxycorticosterone = 18,21-dihydroxypregn-4-ene-3,20-dione
- 18-Hydroxycorticosterone = 11β,18,21-trihydroxypregn-4-ene-3,20-dione
- 18-Hydroxyprogesterone = 18-hydroxypregn-4-ene-3,20-dione
- 21-Deoxycortisol = 11β,17α-dihydroxypregn-4-ene-3,20-dione,
- 21-Deoxycortisone = 17α-hydroxypregn-4-ene-3,11,20-trione
- 21-Hydroxypregnenolone = 3β,21-dihydroxypregn-5-en-20-one
- Aldosterone = 11β,21-dihydroxypregn-4-ene-3,18,20-trione
- Corticosterone = 11β,21-dihydroxypregn-4-ene-3,20-dione
- Cortisol = 11β,17α,21-trihydroxypregn-4-ene-3,20-dione
- Cortisone = 17α,21-dihydroxypregn-4-ene-3,11,20-trione
- Pregnenolone = pregn-5-en-3β-ol-20-one
- Progesterone = pregn-4-ene-3,20-dione
The above list includes precursors and intermediates in corticosteroid biosynthesis.
Synthetic
Progesterone-type
- Flugestone = 9α-fluoro-11β,17α-dihydroxypregn-4-ene-3,20-dione
- Fluorometholone = 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione
- Medrysone = 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione
- Prebediolone acetate = 3β,21-dihydroxypregn-5-en-20-one 21-acetate
Hydrocortisone-type
- Chloroprednisone = 6α-chloro-17α,21-dihydroxypregna-1,4-diene-3,11,20-trione
- Cloprednol = 6-chloro-11β,17α,21-trihydroxypregna-1,4,6-triene-3,20-dione
- Difluprednate = 6α,9α-difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17α-butyrate 21-acetate
- Fludrocortisone = 9α-fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione
- Fluocinolone = 6α,9α-difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
- Fluperolone = 9α-fluoro-11β,17α,21-trihydroxy-21-methylpregna-1,4-diene-3,20-dione
- Fluprednisolone = 6α-fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
- Loteprednol = 11β,17α,dihydroxy-21-oxa-21-chloromethylpregna-1,4-diene-3,20-dione
- Methylprednisolone = 6α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
- Prednicarbate = 11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17α-ethylcarbonate 21-propionate
- Prednisolone = 11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
- Prednisone = 17α,21-dihydroxypregna-1,4-diene-3,11,20-trione
- Tixocortol = 11β,17α-dihydroxy-21-sulfanylpregn-4-ene-3,20-dione
- Triamcinolone = 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
Methasone-type (16-methylated)
- Alclometasone = 7α-chloro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Beclometasone = 9α-chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- Betamethasone = 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- Clobetasol = 9α-fluoro-11β,17α-dihydroxy-16β-methyl-21-chloropregna-1,4-diene-3,20-dione
- Clobetasone = 9α-fluoro-16β-methyl-17α-hydroxy-21-chloropregna-1,4-diene-3,11,20-trione
- Clocortolone = 6α-fluoro-9α-chloro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Desoximetasone = 9α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Dexamethasone = 9α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Diflorasone = 6α,9α-difluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- Difluocortolone = 6α,9α-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Fluclorolone = 6α-fluoro-9α,11β-dichloro-16α,17α,21-trihydroxypregna-1,4-dien-3,20-dione
- Flumetasone = 6α,9α-difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Fluocortin = 6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20,21-trione
- Fluocortolone = 6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Fluprednidene = 9α-fluoro-11β,17α,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione
- Fluticasone = 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione
- Fluticasone furoate = 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione 17α-
- Halometasone = 2-chloro-6α,9α-difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Meprednisone = 16β-methyl-17α,21-dihydroxypregna-1,4-diene-3,11,20-trione
- Mometasone = 9α,21-dichloro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Mometasone furoate = 9α,21-dichloro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17α-
- Paramethasone = 6α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Prednylidene = 11β,17α,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione
- Rimexolone = 11β-hydroxy-16α,17α,21-trimethylpregna-1,4-dien-3,20-dione
- Ulobetasol = 6α,9α-difluoro-11β,17α-dihydroxy-16β-methyl-21-chloropregna-1,4-diene-3,20-dione
Acetonides and related
- Amcinonide = 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with cyclopentanone, 21-acetate
- Budesonide = 11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with butyraldehyde
- Ciclesonide = 11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with -cyclohexanecarboxaldehyde, 21-isobutyrate
- Deflazacort = 11β,21-dihydroxy-2'-methyl-5'H-pregna-1,4-dienooxazole-3,20-dione 21-acetate
- Desonide = 11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with acetone
- Formocortal = 3--9α-fluoro-11β,16α,17α,21-tetrahydroxy-20-oxopregna-3,5-diene-6-carboxaldehyde cyclic 16α,17α-acetal with acetone, 21-acetate
- Fluclorolone acetonide = 6α-fluoro-9α,11β-dichloro-16α,17α,21-trihydroxypregna-1,4-dien-3,20-dione cyclic 16α,17α-acetal with acetone
- Fludroxycortide = 6α-fluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione cyclic 16α,17α-acetal with acetone
- Flunisolide = 6α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with acetone
- Fluocinolone acetonide = 6α,9α-difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with acetone
- Fluocinonide = 6α,9α-difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with acetone, 21-acetate
- Halcinonide = 9α-fluoro-11β,16α,17α-trihydroxy-21-chloropregn-4-ene-3,20-dione cyclic 16α,17α-acetal with acetone
- Triamcinolone acetonide = 9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16α,17α-acetal with acetone
Others
- Cortivazol = 6,16α-dimethyl-11β,17α,21-trihydroxy-2'-phenylpyrazolopregna-4,6-dien-20-one 21-acetate
- RU-28362 = 6-methyl-11β,17β-dihydroxy-17α-androsta-1,4,6-trien-3-one