List of highest-grossing Filipino films in 2012
The following are Filipino films that earned at least 50 million pesos in 2012 during their screenings.
| Rank | Film | Production outfit | Film released | Domestic gross | Source |
| 1. | Sisterakas | Star Cinema, Viva Films | December 25 | ₱ 391,000,000 | |
| 2. | The Mistress | Star Cinema | September 12 | ₱ 262,790,230 | |
| 3. | This Guy's in Love with U Mare! | Star Cinema, Viva Films | October 10 | ₱ 249,105,182 | |
| 4. | One More Try | Star Cinema | December 25 | ₱ 205,000,000 | |
| 5. | ÜnOfficially Yours | Star Cinema | February 15 | ₱ 157,254,200 | |
| 6. | Kimmy Dora and the Temple of Kiyeme | Spring Films, Star Cinema | June 13 | ₱ 133,963,009 | |
| 7. | Si Agimat, si Enteng Kabisote at si Ako | OctoArts Films, GMA Films | December 25 | ₱ 133,500,000 | |
| 8. | A Secret Affair | Viva Films | October 24 | ₱ 118,424,018 | |
| 9. | The Healing | Star Cinema | July 25 | ₱ 104,602,460 | |
| 10. | ' | GMA Films, Reality Entertainment | October 17 | ₱ 83,792,136 | |
| 11. | 24/7 in Love | Star Cinema | November 21 | ₱ 75,057,886 | |
| 12. | The Reunion | Star Cinema | August 15 | ₱ 68,112,967 | |
| 13. | Moron 5 and the Crying Lady | Viva Films, MVP Pictures | April 7 | ₱ 64,642,363 | |
| 14. | Born to Love You | Star Cinema | May 30 | ₱ 52,022,257 | |
| 15. | ' | Skylight Films, Reality Entertainment | March 14 | ₱ 51,389,780 | |
| 16. | Every Breath U Take | Star Cinema | May 16 | ₱ 50,191,540 |
;Note
- Box Office Mojo, a reliable third party box office revenue tracker, does not track any revenues earned during any Metro Manila Film Festival editions. So the official figures by film entries during the festival are only estimates taken from any recent updates from credible and reliable sources such as a film's production outfit, or from any news agencies. Also, Metro Manila Development Authority did not release the official gross sales of each of the films. To verify the figures, see individual sources for the references.