List of highways numbered 501

• Alberta Highway 501
• County Route 501 (New Jersey)
• Florida State Road 501
• Japan National Route 501
• Manitoba Provincial Road 501
• Maryland Route 501
• Nevada State Route 501
• New Mexico State Road 501
• North Carolina Highway 501
• Ohio State Route 501
• Ontario Highway 501
• Oregon Route 501
• Pennsylvania Route 501
• Puerto Rico Highway 501
• South Carolina Highway 501
• U.S. Route 501
• Washington State Route 501
• West Virginia Route 501