List of investigational anxiolytics

Generalized anxiety disorder

• Agomelatine – melatonin MT₁ and MT₂ receptor agonist, 5-HT_2C receptor antagonist
• Riluzole sublingual – undefined mechanism of action
• TGFK08AA – 5-HT_1A receptor modulator
• TGW00AA – 5-HT_1A receptor agonist, 5-HT_2A receptor antagonist
• Vilazodone – 5-HT_1A receptor partial agonist and serotonin reuptake inhibitor
• Vortioxetine – serotonin reuptake inhibitor, 5-HT_1A receptor agonist, and 5-HT₃ and 5-HT₇ receptor antagonist

  Panic disorder

• NBTX-001 – NMDA receptor antagonist

  Post-traumatic stress disorder

• 7-Oxoprasterone – "immunomodulator" / undefined mechanism of action
• Acamprosate – undefined mechanism of action
• BNC-210 – " modulator" / undefined mechanism of action
• Brexpiprazole – atypical antipsychotic / 5-HT_1A, D₂ and D₃ receptor partial agonist and 5-HT_2A, 5-HT_2B, 5-HT₇, α₁-adrenergic, α₂-adrenergic, and H₁ receptor antagonist
• Cyclobenzaprine – undefined mechanism of action
• Iloperidone – atypical antipsychotic / 5-HT_2A, 5-HT₆, 5-HT₇, D₂, D₃, D₄, and α₁-adrenergic receptor antagonist
• MDMA – serotonin–norepinephrine–dopamine releasing agent and 5-HT₁ and 5-HT₂ receptor agonist – specifically under development as an aid to psychotherapy for post-traumatic stress disorder
• NBTX-001 – NMDA receptor antagonist
• Pomaglumetad methionil – mGluR₂ and mGluR₃ agonist
• Tianeptine oxalate – atypical μ-opioid receptor agonist
• Verucerfont – CRF₁ receptor antagonist

  Social anxiety disorder

• 4-Androstadienol – vomeropherine / neurosteroid
• Fluvoxamine extended release - Serotonin uptake inhibitors.
• Riluzole sublingual – "glutamate modulator" / undefined mechanism of action
• TGW00AA – 5-HT_1A receptor agonist, 5-HT_2A receptor antagonist
• Verucerfont – CRF₁ receptor antagonist
• Vilazodone – 5-HT_1A receptor partial agonist and serotonin reuptake inhibitor
• Vortioxetine – serotonin reuptake inhibitor, 5-HT_1A receptor agonist, and 5-HT₃ and 5-HT₇receptor antagonist
• JNJ-42165279 - FAAH inhibitor

  unspecified

• AVN-101 – 5-HT₆ receptor antagonist
• BNC-210 – "GABA modulator" / undefined mechanism of action
• JNJ-42165279 – FAAH inhibitor
• MP-20X – CB₁ and 5-HT_1A receptor modulator
• SRX-246 – vasopressin V_1A receptor antagonist