List of people named O'Brien
O'Brien or Brien is a surname of Irish origin which has many variants in the Irish diaspora worldwide, such as O'Bryan, O'Brian, O'Briant, O'Brient, O'Bryant, O'Brine, O'Bryen etc., which all claim a general common ancestry with the original Gaelic surname being Ó Briain. Notable people with the surname include:
Real people
A
- Aidan O'Brien, Irish race horse trainer
- Alan O'Brien, Irish association football player
- Alex O'Brien, professional American tennis player
- Ambrose O'Brien
- Andy O'Brien, various
- Anne O'Brien, various
- Arthur O'Brien
- Austin O'Brien
B
- Barry O'Brien
- Billy O'Brien , American baseball player
- Billy O'Brien, Welsh association football player
- Brendan O'Brien, various
- Brenna O'Brien
- Brock O'Brien
- Buck O'Brien
- Burton O'Brien
C
- Cathy O'Brien , American long-distance runner
- Cathy O'Brien , purported American child-slave/sex-abuse victim
- Charles O'Brien, various
- Christian O'Brien, British geologist, author & historian
- Ciaran O'Brien
- Chris Brien, a drummer
- Cinders O'Brien
- Clinton O'Brien, Australian rugby league footballer
- Conal O'Brien
- Conan O'Brien, US comedian and talk show host
- Connor O'Brien
- Conor O'Brien, various
- Cubby O'Brien
D
- Daniel O'Brien, various
- Danielle O'Brien
- Danny O'Brien, various
- Dara Ó Briain, Irish comedian and presenter
- Darcy O'Brien, American true crime author
- Daryl O'Brien, Australian footballer
- Dave O'Brien , American film actor
- Dave O'Brien, American sportscaster
- David O'Brien, various
- Doug Brien, former American football placekicker
- Don Brien, Canadian sprint canoer, who competed in the mid to late 1980s
- Declan O'Brien, president of Utopia Pictures & Television, and a writer and producer
- Declan O'Brien
- Dennis O'Brien, various
- Derek O'Brien, various
- Dermod O'Brien, Irish painter
- Donald O'Brien, various
- Doug O'Brien
- Dylan O'Brien, American actor
E
- Ed O'Brien,, English musician
- Edmond O'Brien
- Edna O'Brien, Irish novelist
- Edward O'Brien, various
- Edwin Frederick O'Brien, Grand Master of the Equestrian Order of the Holy Sepulchre of Jerusalem
- Eileen O'Brien, various
- Elaine O'Brien, American politician
- Erin O'Brien, American writer
- Erin Joanne O'Brien, American actress
- Eugene O'Brien, various
F
- Fergal O'Brien, Irish professional snooker player
- Fergus O'Brien
- Fitz James O'Brien, Irish born American novelist
- Flann O'Brien, pen name of Irish novelist and satirist Brian O'Nolan
G
- Gareth O'Brien
- Geraldine O'Brien
- George O'Brien, various
- Ger O'Brien
- Geoffrey O'Brien
- Glenn O'Brien
- Gray O'Brien
- Gavin O'Brien
H
- Harry O'Brien
- Harvey O'Brien
- Henry O'Brien, various
- Hod O'Brien, American jazz pianist
- Hugh O'Brien mayor of Boston
I
- Iain O'Brien
- Ian O'Brien
- Ignatius O'Brien, 1st Baron Shandon, Lord Chancellor of Ireland, 1913–1918
J
- Jack O'Brien, various
- Jake O'Brien
- James O'Brien
- Jamie O'Brien, various
- Jeremiah O'Brien, US Navy officer of the American Revolutionary War
- Jesse O'Brien, various
- Jim O'Brien
- Joan O'Brien
- Joe O'Brien, various
- Joey O'Brien
- John O'Brien, various
- Joseph O'Brien, various
K
- Kate O'Brien
- Katharine O'Brien
- Katherine O'Brien
- Kathleen O'Brien
- Katie O'Brien, British female tennis player
- Keith O'Brien, Roman Catholic Cardinal Archbishop of Saint Andrews and Edinburgh
- Ken O'Brien
- Kerry O'Brien
- Kevin O'Brien, various
- Kieran O'Brien
- Kim O'Brien, American film and television actress
- Kirsten O'Brien, British TV presenter
- Kitt O'Brien, American football player
- Kitty Wilmer O'Brien, Irish painter
L
- Larry O'Brien, American politician
- Larry O'Brien, Canadian entrepreneur and politician; Mayor of Ottawa, 2006–2010
- Laurence O'Brien
- Lawrence O'Brien
- Leighton O'Brien
- Lévis Brien, Quebec politician
- Leo O'Brien, various
- Leonora O'Brien, Irish pharmacist and entrepreneur
- Leslie O'Brien
- Liam O'Brien, various
- Lucy O'Brien
- Luke O'Brien
M
- Margaret O'Brien
- Mariah O'Brien
- Mark O'Brien, various
- Matthew O'Brien, Irish mathematician
- Maureen O'Brien
- Michael O'Brien, various
- Michele O'Brien
- Mick O'Brien, various
- Mike O'Brien
- Miles O'Brien, various
- Mollie O'Brien
N
- Niall O'Brien, various
- Nick O'Brien
O
- Olivia O'Brien, American singer and songwriter
P
- Paddy O'Brien, various
- Parry O'Brien
- Patrick O'Brien, for people with forename Patrick or Pat
- Pat O'Brien, various
- Paul O'Brien, various
- Peter O'Brien, various
R
- Raymond O'Brien, American Roman Catholic priest
- Richard O'Brien, various
- Robert O'Brien, various
- Rory Brien
- Ron O'Brien, various
- Roy O'Brien
S
- Scott O'Brien
- Sean O'Brien
- Shane O'Brien, various
- Shannon O'Brien
- Sicele O'Brien, Irish aviator
- Simon O'Brien, various
- Soledad O'Brien, American television journalist
- Stephen O'Brien, UK conservative politician for Eddisbury
- Stuart O'Brien, lead guitarist of rock band Amnezia
T
- Terence O'Brien, various
- Thomas O'Brien, various
- Tim O'Brien, various
- Timothy O'Brien , British theatre designer
- Timothy O'Brien, Irish professor
- Timothy L. O'Brien, American journalist
- Tina O'Brien, English actress
- Tom O'Brien , American film actor
- Tom O'Brien , American college football coach at North Carolina State University
- Tom O'Brien , baseball outfielder
- Tom O'Brien , 19th century baseball player
- Tom O'Brien , British trade unionist and Member of Parliament
- Tommy O'Brien, baseball outfielder
- Trever O'Brien
U
- Una O'Brien, British civil servant
V
- Vincent O'Brien, various
- Virginia O'Brien
W
- Walter O'Brien, Computer expert and Irish businessman
- Walter A. O'Brien, American Progressive Party politician
- William O'Brien, various
- Willis O'Brien
Z
- Zach O'Brien, professional ice hockey player
Fictional people named O'Brien
- O'Brien, a character in George Orwell's novel Nineteen Eighty-Four
- Lady Cassandra O'Brien, fictional character, Doctor Who antagonist
- Chloe O'Brian, a fictional character played by actress Mary Lynn Rajskub on the US television series 24
- Graham O'Brien, a companion of the Thirteenth Doctor in the BBC series Doctor Who
- Keiko O'Brien, fictional character, wife of Miles O'Brien in Star Trek: The Next Generation and Deep Space Nine
- Miles O'Brien, a fictional character in Star Trek: The Next Generation and Deep Space Nine
- Sarah O'Brien, a fictional character on the ITV series Downton Abbey
- Shelia O'Brian, a character from the TV Cartoon series Dungeons and Dragons
- Mr. O'Brien, Mrs. O'Brien and Jack O'Brien, fictional characters in The Tree of Life