Perrantes attended Crespi Carmelite High School, where he was coached by Russell White. Perrantes developed his signature calm, deliberate playing style after competing against older players. He was noticed by Washington State football player Nico Grasu, who alerted the university's basketball coach, Tony Bennett. When Bennett was hired by Virginia, Perrantes committed to play for him, turning down an offer from USC after Kevin O'Neill was released as coach. As a senior, he averaged 19.9 points and 5.8 assists per game and was named L.A. Daily NewsPlayer of the Year and L.A. Times All-Area First Team. He was ranked No. 86 on ESPN's Top 100 recruiting list for 2013.
College career
As a freshman, Perrantes led Virginia to the NCAA Tournament's Sweet 16 for the first time in 19 years while starting 33 games and shooting 44% from behind the arc. On the season, he averaged 5.5 points and a team-high 3.8 assists per game. He was suspended the first game of his sophomore season for violating undisclosed team rules. He scored a career-high 26 points in a match against Miami on January 1, 2015. Perrantes broke his nose and suffered a mild concussion after colliding with Malcolm Brogdon in a win against Florida State on February 22. He averaged 6.4 points and 4.6 assists per game as a sophomore, leading the Cavaliers to a 30–4 record and second straight Atlantic Coast Conference regular-season title. As a junior, Perrantes became more of a vocal leader on the team, identifying himself as the player who picked the team up when it was dragging. He hit a career-high seven three-pointers to go along with 22 points in a loss to Virginia Tech on January 4, 2016. Perrantes scored 16 points with four 3-pointers in a 73–65 win against Syracuse on January 24. Perrantes averaged 11.0 points, 4.4 assists and 3.0 rebounds per game, shooting 43.9 percent from the field, 48.8 percent from 3-point range and 80.3 percent from the free-throw line. He was named honorable mention All-ACC by the media and coaches. "He just stirred the pot," coach Bennett said of Perrantes in 2016. "He made everything kind of work out. He got guys the ball. He understood it." As a senior, Perrantes was named to the Second Team All-Atlantic Coast Conference. His season ended with a 65–39 loss to Florida in the NCAA Tournament. Perrantes averaged 12.7 points and 3.8 assists per game. He tied a program record with 138 games played and scored 1,225 points in his Virginia career.
Professional career
After going undrafted in the 2017 NBA Draft, Perrantes signed a summer league deal with the Miami Heat. On August 23, 2017, Perrantes signed with the San Antonio Spurs. He was waived before the season began on October 12, 2017. On October 18, 2017, Perrantes signed a two-way contract with the Cleveland Cavaliers. That meant throughout the rest of that season, he had split his playing time between the Cavaliers and their NBA G League affiliate, the Canton Charge. Perrantes would make his NBA debut on December 12, playing three minutes in a 123–114 win over the Atlanta Hawks. The Cavaliers made it to the 2018 NBA Finals, but lost 4-0 to the Golden State Warriors. On June 12, 2018, Perrantes was waived by the Cavaliers. On July 23, 2018, Perrantes signed a one-year deal with French side Limoges. On November 16, 2018, Perrantes was released by Limoges CSP. On November 18, 2018, Perrantes joined Cholet Basket. On June 25, 2019, Perrantes joined the New Orleans Pelicans for the 2019 NBA Summer League. On September 12, 2019, Perrantes joined the Portland Trail Blazers for training camp, but was later waived by the Portland Trail Blazers on October 18. On November 11, 2019, Perrantes joined the Bahçeşehir Basketbol. On January 21, 2020, the Capital City Go-Go announced that they had acquired Perrantes from Canton Charge in exchange for the returning right to Gabe York.
